product name
L -肉碱 盐酸盐, synthetic, ≥98%
生物来源
synthetic
质量水平
检测方案
≥98%
形式
powder
颜色
white
mp
142 °C
应用
cell analysis
SMILES字符串
[Cl-].C[N+](C)(C)C[C@H](O)CC(O)=O
InChI
1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m1./s1
InChI key
JXXCENBLGFBQJM-FYZOBXCZSA-N
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应用
L-肉碱盐酸盐已被用于研究麦角硫因素转运蛋白 SLC22A4 和肉毒碱转运蛋白 SLC22A5。它还被用于使棕榈酸进入线粒体。
生化/生理作用
肉碱是由赖氨酸生物合成的。它可能与支链氨基酸的能量产生有关。
肉毒碱是季铵，天然存在于大多数哺乳动物组织中。它在骨骼肌和心脏中参与能量代谢调控，浓度相对较高。它可将葡萄糖代谢由糖酵解转移至糖原储存，并促进长链脂肪酸向线粒体转运，使其在线粒体氧化产生能量。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
K Kasperek et al.
Polish journal of veterinary sciences, 21(4), 811-813 (2019-01-04)
The aim of our study was to determine the influence of L-carnitine (L-CAR) on the cellular parameters of hen erythrocytes during a 48 hour exposure to L-CAR at concentrations of 25, 50 and 100 µg/mL in nutrient-deficient medium. Cell morphology
R E L Cabral et al.
Andrology, 6(1), 236-246 (2017-10-04)
Doxorubicin has been largely used in anticancer therapy in adults, adolescents, and children. The efficacy of l-carnitine as an antioxidant substance has been confirmed both in humans and rats. Carnitine, present in testis and epididymis, is involved in sperm maturation.
Isabelle Lelong-Rebel et al.
Anticancer research, 28(1A), 55-68 (2008-04-04)
Two chemosensitive cell lines, LoVo-fusoid (LoVo-f) and LoVo-small cells (LoVo-sc) were derived from the original LoVo cell line. These two variants and the multidrug-resistant (MDR) cell line LoVo-Dox were screened for various properties. In non-permeabilized cells, only LoVo-sc showed mucin-2
Giulia Mollica et al.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 52(3), 314-323 (2019-10-15)
Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disorder. NAFLD, associated lipotoxicity, fibrosis, oxidative stress, and altered mitochondrial metabolism, is responsible for systemic inflammation, which contributes to organ dysfunction in extrahepatic tissues, including the heart. We
Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: Gain-of-function by interchange of selected amino acids
Petra Bacher.
Biochimica et Biophysica Acta, 1788(12), 2594-2602 (2009)
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