C0158
L -肉碱 内盐
≥98%
别名:
左旋肉毒碱, 维生素 BT
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线性分子式:
(CH3)3N+CH2CH(OH)CH2COO-
化学文摘社编号:
分子量:
161.20
Beilstein:
4292315
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.79
产品名称
L -肉碱 内盐, synthetic, ≥98%
生物来源
synthetic
质量水平
方案
≥98%
表单
powder
颜色
white
mp
197-212 °C (lit.)
应用
cell analysis
detection
SMILES字符串
C[N+](C)(C)C[C@H](O)CC([O-])=O
InChI
1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
InChI key
PHIQHXFUZVPYII-ZCFIWIBFSA-N
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应用
L-肉碱内盐已被用作Seahorse XF线粒体应激测定中的测定培养基的组分。它还被口服给予荷瘤小鼠，以研究其对过氧化物酶体增殖物激活受体的调节作用，从而对肝脏炎症反应进行分析。
生化/生理作用
肉毒碱是一种天然存在于大多数哺乳动物组织中的季铵。它在骨骼肌和心脏中参与能量代谢调控，浓度相对较高。它可将葡萄糖代谢由糖酵解转移至糖原储存，并促进长链脂肪酸向线粒体转运，使其在线粒体氧化产生能量。
肉碱由赖氨酸生物合成。肉碱可促进脂肪酸转运至线粒体区室中。在骨骼肌和心肌组织中，它充当代谢辅助因子。肉碱可能与支链氨基酸的能量产生有关。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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