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About This Item
经验公式（希尔记法）:
C17H23NO6
CAS号:
分子量:
337.37
Beilstein:
2482076
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
product name
Boc-Glu-OBzl,
检测方案
≥98% (TLC)
质量水平
形式
powder
颜色
white to off-white
mp
95-99 °C
应用
peptide synthesis
储存温度
−20°C
SMILES字符串
CC(C)(C)OC(=O)N[C@@H](CCC(O)=O)C(=O)OCc1ccccc1
InChI
1S/C17H23NO6/c1-17(2,3)24-16(22)18-13(9-10-14(19)20)15(21)23-11-12-7-5-4-6-8-12/h4-8,13H,9-11H2,1-3H3,(H,18,22)(H,19,20)/t13-/m0/s1
InChI key
CVZUKWBYQQYBTF-ZDUSSCGKSA-N
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生化/生理作用
Boc-Glu-OBzl is an N-terminal protected amino acid used in solid-phase peptide synthesis (SPPS) to make unique peptides containing glutamate benzyl ester residues.
底物
Substrate for Vitamin K-dependent carboxylation.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Structure-activity studies on prolactin-releasing peptide (PrRP). Analogues of PrRP-(19-31)-peptide.
Robert G Boyle et al.
Journal of peptide science : an official publication of the European Peptide Society, 11(3), 161-165 (2005-01-07)
An investigation of a series of single replacement analogues of PrRP-(19-31)-peptide has shown that good functional activity was retained when Phe31 was replaced with His(Bzl), Phe(4Cl), Nle, Trp, Cys(Bzl) or Glu(OBzl); when Val28 or Ile25 was replaced with Phg; when
K H Hsieh et al.
International journal of peptide and protein research, 48(3), 292-298 (1996-09-01)
Side reactions in peptide synthesis indicate steps needing improvement as well as opportunities for structural diversification in combinatorial design. Among the side reactions observed in this study, transesterification of Boc-Glu(OBzl) occurred in TMAH-catalyzed resin attachment, leading to Boc-DKKREE(OMe) in solid-phase
E I Lepist et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 11(1), 43-50 (2000-07-29)
One approach to increase drug stability and to facilitate oral absorption of low bioavailability drugs may be to design oligopeptide ester prodrugs which are stable in the gastrointestinal tract, are transported via the oligopeptide transporter, and finally release the parent
S Romiti et al.
Journal of biochemical and biophysical methods, 11(1), 59-68 (1985-05-01)
Methods are presented that describe alternative protocols for the isolation of rat liver microsomes containing the vitamin K-dependent carboxylase and the procedure in which the solubilized enzyme is assayed. The method for determining the rate of 14CO2 incorporation into low
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