所有图片(3)
别名:
8-Br-cAMP
经验公式（希尔记法）:
C10H10BrN5NaO6P
CAS号:
分子量:
430.08
Beilstein:
7739743
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
检测方案
≥97% (HPLC)
形式
powder
颜色
off-white
溶解性
H2O: 100 mg/mL
储存温度
−20°C
SMILES字符串
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc12
InChI
1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChI key
DMRMZQATXPQOTP-GWTDSMLYSA-M
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相关类别
一般描述
8-溴腺苷3′,5′-环单磷酸是溴化环单核苷酸。
应用
8-溴腺苷3′,5′-环单磷酸钠盐用于：
- 研究其对牛黄体中期细胞fas和caspase-3 mRNA表达以及P4产量的影响
- 用于治疗绒毛膜癌BeWo细胞系，研究其对细胞活力，细胞凋亡和细胞核形态变化的影响
- 在灌注介质中刺激头肾
生化/生理作用
比 cAMP 更抗磷酸二酯酶水解的细胞通透性 cAMP 类似物。激活培养细胞的蛋白激酶 A、抑制生长、减少增殖、增加分化并诱导凋亡。
特点和优势
该化合物是环核苷酸研究的特色产品。点击此处查看更多特色环核苷酸产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
其他说明
膜渗透性 cAMP 类似物。
注意
对光和水分敏感。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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The Journal of Endocrinology, 193(3), 349-357 (2007)
Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)
Chen Y, et al.
Reproductive Biology and Endocrinology, 11(1), 30-30 (2013)
Congying Wang et al.
Molecular pain, 3, 22-22 (2007-08-19)
Prostaglandin E2 (PGE2) is a well-known inflammatory mediator that enhances the excitability of DRG neurons. Homomeric P2X3 and heteromeric P2X2/3 receptors are abundantly expressed in dorsal root ganglia (DRG) neurons and participate in the transmission of nociceptive signals. The interaction
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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