推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
off-white
溶解性
DMSO: >20 mg/mL
H2O: insoluble
创始人
Abbott
SMILES字符串
Cl[H].OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4
InChI
1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H
InChI key
RDNLAULGBSQZMP-UHFFFAOYSA-N
基因信息
human ... CHRM1(1128)
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生化/生理作用
Antiparkinsonian; non-selective muscarinic receptor antagonist.
Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Elmorsy Khaled et al.
Talanta, 87, 40-45 (2011-11-22)
The construction and performance characteristics of Biperiden (BP) polyvinyl chloride (PVC) electrodes are described. Different methods for electrode fabrication are tested including; incorporation of BP-ion pairs (BP-IPs), incorporation of ion pairing agents, or soaking the plain electrode in BP-ion pairs
Marina S Zacarias et al.
Neuroscience letters, 513(2), 129-131 (2012-02-18)
It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and
Use of anticholinergic drugs and worsening of pemphigus foliaceus in a patient with bipolar disorder.
Lúcio Botelho-Nogueira et al.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 33(4), 412-413 (2011-12-23)
A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden.
Sakae Takahashi et al.
The Journal of neuropsychiatry and clinical neurosciences, 25(1), E28-E28 (2013-03-15)
W Sperling et al.
Medical hypotheses, 76(5), 720-722 (2011-03-04)
In a regions of interest analysis (ROI) of the most frequent psychiatric disorders (schizophrenia, depression, anxiety, addiction), we found the nucleus lentiformis to be the topographical brain region most frequently cited in connection with these disorders in a regions of
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
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