B5311
盐酸比哌立登 盐酸盐
≥98% (HPLC), powder
别名:
1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride, Akineton, Akinophyl
InChI key
RDNLAULGBSQZMP-UHFFFAOYSA-N
InChI
1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H
SMILES string
Cl[H].OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4
assay
≥98% (HPLC)
form
powder
color
off-white
solubility
DMSO: >20 mg/mL, H2O: insoluble
originator
Abbott
Quality Level
Gene Information
human ... CHRM1(1128)
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Biochem/physiol Actions
Antiparkinsonian; non-selective muscarinic receptor antagonist.
Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Biperiden-induced delirium in an adolescent patient.
Liang-Jen Wang et al.
Journal of child and adolescent psychopharmacology, 21(5), 499-500 (2011-11-02)
Svjetlana Loga-Zec et al.
Psychiatria Danubina, 23(1), 60-63 (2011-03-31)
Polypharmacy in psychiatry is becoming the rule rather than the exception. Using more drugs at same time usually occurs where single drugs are considered insufficiently effective. The sample consisted of 216 patients: 85 from Sarajevo, and 44 and 87 respectively
Hormoz Ayromlou et al.
Archives of Iranian medicine, 14(2), 152-154 (2011-03-03)
The syndrome of hemiparkinsonism-hemiatrophy is an uncommon form of secondary Parkinsonism that presents with unilateral body Parkinsonism plus variable atrophy on the same side. Diagnosis of this syndrome needs a complete past medical history taking, as well as assessment of
A V Karabanov et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(9), 41-46 (2012-12-14)
Treatment of dystonia is a complex problem of current neurology due to the etiological and neurochemical heterogeneity of this clinical syndrome. Central cholinolytics is a most effective group of drugs for patients with dystonia and dystonic tremor. The authors present
Inge Klinkenberg et al.
The international journal of neuropsychopharmacology, 15(10), 1375-1385 (2011-11-19)
Learned irrelevance (LIrr) refers to a reduction in associative learning after pre-exposure of the conditioned and unconditioned stimulus in a non-contingent fashion. This paradigm might serve as a translational model for (pre)attentive information processing deficits in schizophrenia. This is the
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
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