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安全信息

B3398

Sigma-Aldrich

单克隆抗 人 IgG2

clone HP-6014, purified from hybridoma cell culture

别名:

Monoclonal Anti-Human IgG2

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.46

生物来源

mouse

质量水平

偶联物

biotin conjugate

抗体形式

purified from hybridoma cell culture

抗体产品类型

secondary antibodies

克隆

HP-6014, monoclonal

表单

buffered aqueous solution

种属反应性

human

技术

direct ELISA: 1:30,000

同位素/亚型

IgG1

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

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一般描述

Monoclonal Anti-Human IgG2 (mouse IgG1 isotype) is derived from the hybridoma (HP-60141 ) produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. IgG is the most abundant serum immunoglobulins of the immune system. IgG2 is a subtype of IgG. IgG is secreted by B cells and is found in blood and extracellular fluids.

特异性

该抗体对人 IgG2 具有特异性,与其他 IgG 亚类不反应。该克隆已被 IUIS/WHO 研究挑选出为应用最广泛的 IgG2 特异性单克隆抗体。

应用

Monoclonal Anti-Human IgG2−Biotin antibody produced in mouse has been used in indirect enzyme linked immunosorbent assay (ELISA) and immunoblot.

生化/生理作用

IgG provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
Low IgG2 levels were found in patients with systemic lupus erythematosus (SLE) and juvenile diabetes melitus.

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Immunoglobulin subclass deficiency
Hanson L A, et al.
The Pediatric Infectious Disease Journal, 7, 7-21 (1988)
Nadia Ben Nouir et al.
Journal of clinical microbiology, 46(5), 1631-1640 (2008-03-28)
Echinococcus granulosus protoscolex soluble somatic antigens (PSSAs) were assessed for their prognostic value in the serological follow-up of young patients treated for cystic echinococcosis (CE), compared to conventional hydatid fluid (HF) antigen. Based on different clinical courses and outcome of
Elana R Shaw et al.
Current protocols, 2(8), e511-e511 (2022-08-18)
Autoantibodies (autoAbs) that neutralize type 1 interferons (T1IFNs) are a major risk factor associated with developing critical COVID-19 disease and are most commonly found in individuals over age 70 and in patients with genetic or acquired thymic defects. Swift identification
Karen Cortés-Sarabia et al.
Viruses, 15(4) (2023-04-28)
Background: COVID-19 vaccination or natural infection is associated with the development of immunity. The search of IgA and IgG antibodies against all the structural proteins (spike, nucleocapsid, membrane, and envelope) of SARS-CoV-2 in breastfeeding mothers is associated with immunity that
Marianna Spatola et al.
Neurology, 95(22), e3012-e3025 (2020-09-16)
To clinically characterize patients with anti-metabotropic glutamate receptor (mGluR) 1 encephalitis, to identify prognostic factors, and to study the immunoglobulin G (IgG) subclasses and effects of antibodies on neuronal mGluR1 clusters. Clinical information on new and previously reported patients was

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