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Merck
CN

B3398

单克隆抗 人 IgG2

clone HP-6014, purified from hybridoma cell culture

别名:

Monoclonal Anti-Human IgG2

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关于此项目

NACRES:
NA.46
UNSPSC Code:
12352203
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产品名称

单克隆抗 人 IgG2, clone HP-6014, purified from hybridoma cell culture

biological source

mouse

conjugate

biotin conjugate

antibody form

purified from hybridoma cell culture

antibody product type

secondary antibodies

clone

HP-6014, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

direct ELISA: 1:30,000

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

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Biochem/physiol Actions

该抗体对人 IgG2 具有特异性,与其他 IgG 亚类不反应。该克隆已被 IUIS/WHO 研究挑选出为应用最广泛的 IgG2 特异性单克隆抗体。
IgG provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
Low IgG2 levels were found in patients with systemic lupus erythematosus (SLE) and juvenile diabetes melitus.

Application

Monoclonal Anti-Human IgG2−Biotin antibody produced in mouse has been used in indirect enzyme linked immunosorbent assay (ELISA) and immunoblot.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Human IgG2 (mouse IgG1 isotype) is derived from the hybridoma (HP-60141 ) produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. IgG is the most abundant serum immunoglobulins of the immune system. IgG2 is a subtype of IgG. IgG is secreted by B cells and is found in blood and extracellular fluids.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Immunoglobulin subclass deficiency
Hanson L A, et al.
The Pediatric Infectious Disease Journal, 7, 7-21 (1988)
Nadia Ben Nouir et al.
Journal of clinical microbiology, 46(5), 1631-1640 (2008-03-28)
Echinococcus granulosus protoscolex soluble somatic antigens (PSSAs) were assessed for their prognostic value in the serological follow-up of young patients treated for cystic echinococcosis (CE), compared to conventional hydatid fluid (HF) antigen. Based on different clinical courses and outcome of
Elana R Shaw et al.
Current protocols, 2(8), e511-e511 (2022-08-18)
Autoantibodies (autoAbs) that neutralize type 1 interferons (T1IFNs) are a major risk factor associated with developing critical COVID-19 disease and are most commonly found in individuals over age 70 and in patients with genetic or acquired thymic defects. Swift identification
Karen Cortés-Sarabia et al.
Viruses, 15(4) (2023-04-28)
Background: COVID-19 vaccination or natural infection is associated with the development of immunity. The search of IgA and IgG antibodies against all the structural proteins (spike, nucleocapsid, membrane, and envelope) of SARS-CoV-2 in breastfeeding mothers is associated with immunity that
Tiina Kelkka et al.
Leukemia, 36(9), 2317-2327 (2022-08-05)
In immune aplastic anemia (IAA), severe pancytopenia results from the immune-mediated destruction of hematopoietic stem cells. Several autoantibodies have been reported, but no clinically applicable autoantibody tests are available for IAA. We screened autoantibodies using a microarray containing >9000 proteins

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