跳转至内容
Merck
CN
所有图片(1)

主要文件

查看所有文档

B1686

Sigma-Aldrich

BIO

≥98% (HPLC), powder, GSK-3α/β inhibitor

别名:

(2’Z,3’E)-6-溴靛玉红-3′-肟, 6-BIO, 6BIO

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C16H10BrN3O2
CAS号:
667463-62-9
分子量:
356.17
MDL编号:
MFCD08705318
UNSPSC代码:
12352200
PubChem化学物质编号:
24724412
NACRES:
NA.77

产品名称

BIO, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

protect from light

颜色

dark red

溶解性

DMSO: >5 mg/mL

运输

wet ice

储存温度

2-8°C

SMILES字符串

O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34

InChI

1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+

InChI key

DDLZLOKCJHBUHD-WAVHTBQISA-N

应用

6-溴靛玉红-3′-肟(BIO)已用于以下情形：
  • MTT 3-(4,5-二甲基噻唑-2- 基)-2,5-联苯四唑溴化物)细胞增殖实验
  • 胚胎干细胞(ESC)的培养基补充剂
  • 抑制人真皮乳头细胞(hDPC)中的糖原合成酶激酶3 β (GSK-3β)

生化/生理作用

6-溴靛玉红-3′-肟（BIO）是一种有效的、可逆的、ATP竞争性GSK-3α/β抑制剂，并且是第一种能够维持人和小鼠胚胎干细胞自我更新的药物。通过在无饲养层条件下用GSK-3抑制剂BIO处理，能够将人胚胎干细胞（hESC）维持在未分化状态。
BIO是一种有效的、选择性的、可逆的、ATP竞争性GSK-3α/β抑制剂。

特点和优势

《受体分类和信号转导》手册的 GSK-3 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物是激酶磷酸酶生物学研究推荐产品。点击此处 ，查看更多激酶磷酸酶生物学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。

包装

空气敏感

法律信息

本品适用于 体外 研究和实验室用途，不得用于人类的任何 体内 或治疗用途、兽医应用或制造化学衍生物。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000384575
0000278882
0000384575
0000220374
0000220374

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Andrew R Patterson et al.
Nature communications, 9(1), 430-430 (2018-02-01)
GTPase of immunity-associated protein 5 (Gimap5) is linked with lymphocyte survival, autoimmunity, and colitis, but its mechanisms of action are unclear. Here, we show that Gimap5 is essential for the inactivation of glycogen synthase kinase-3β (GSK3β) following T cell activation.
Human placental extract exerts hair growth-promoting effects through the GSK-3beta signaling pathway in human dermal papilla cells
Kwon TR, et al.
International Journal of Molecular Medicine, 36(4), 1088-1096 (2015)
Xiang Qiu et al.
World journal of gastroenterology, 21(26), 8061-8072 (2015-07-18)
To investigate the therapeutic effects of lutein against non-alcoholic fatty liver disease (NAFLD) and the related underlying mechanism. After 9 d of acclimation to a constant temperature-controlled room (20 °C-22 °C) under 12 h light/dark cycles, male Sprague-Darley rats were randomly divided
Noëmie Jean LeBlanc et al.
Molecular neurobiology, 56(9), 6521-6538 (2019-03-11)
Stroke induces blood-brain barrier (BBB) breakdown, which promotes complications like oedema and hemorrhagic transformation. Administration of recombinant tissue plasminogen activator (rtPA) within a therapeutic time window of 4.5 h after stroke onset constitutes the only existing treatment. Beyond this time window
Anchel De Jaime-Soguero et al.
PLoS genetics, 13(3), e1006682-e1006682 (2017-03-28)
Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent stem cells guarantees their safe use in the clinic. Embryonic stem cells (ESCs) present a fast cell cycle with a short G1 phase. This is due to the lack
查看所有相关文献

商品

Naive Pluripotent Stem Cell Culture in Serum-Free Media

Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.

癌症干细胞：癌症治疗的靶标

培养和表征CSC群体的癌症干细胞培养基、球状体培养板和癌症干细胞标志物。

Cancer Stem Cells: Targets for Cancer Therapy

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门