推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
储存条件
protect from light
颜色
dark red
溶解性
DMSO: >5 mg/mL
运输
wet ice
储存温度
2-8°C
SMILES字符串
O\N=C1\C(Nc2ccccc12)=C3\C(=O)Nc4cc(Br)ccc34
InChI
1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+
InChI key
DDLZLOKCJHBUHD-WAVHTBQISA-N
应用
6-溴靛玉红-3′-肟(BIO)已用于以下情形：
- MTT 3-(4,5-二甲基噻唑-2- 基)-2,5-联苯四唑溴化物)细胞增殖实验
- 胚胎干细胞(ESC)的培养基补充剂
- 抑制人真皮乳头细胞(hDPC)中的糖原合成酶激酶3 β (GSK-3β)
生化/生理作用
6-溴靛玉红-3′-肟（BIO）是一种有效的、可逆的、ATP竞争性GSK-3α/β抑制剂，并且是第一种能够维持人和小鼠胚胎干细胞自我更新的药物。通过在无饲养层条件下用GSK-3抑制剂BIO处理，能够将人胚胎干细胞（hESC）维持在未分化状态。
特点和优势
该化合物是激酶磷酸酶生物学研究推荐产品。点击此处 ，查看更多激酶磷酸酶生物学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
包装
空气敏感
法律信息
本品适用于 体外 研究和实验室用途，不得用于人类的任何 体内 或治疗用途、兽医应用或制造化学衍生物。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Anchel De Jaime-Soguero et al.
PLoS genetics, 13(3), e1006682-e1006682 (2017-03-28)
Understanding the mechanisms regulating cell cycle, proliferation and potency of pluripotent stem cells guarantees their safe use in the clinic. Embryonic stem cells (ESCs) present a fast cell cycle with a short G1 phase. This is due to the lack
Azuma Kimura et al.
Stem cell research, 24, 61-68 (2017-08-27)
While pancreatic islet transplantation achieves insulin independence in type 1 diabetes (T1D) patients, its widespread application is limited by donor tissue scarcity. Pancreatic progenitor cells (PPCs) give rise to all cell types in the pancreas during development. PPCs derived from
Disconnect between alcohol-induced alterations in chromatin structure and gene transcription in a mouse embryonic stem cell model of exposure
Veazey K, et al.
Alcohol, 60(23), 121-133 (2017)
Andrew R Patterson et al.
Nature communications, 9(1), 430-430 (2018-02-01)
GTPase of immunity-associated protein 5 (Gimap5) is linked with lymphocyte survival, autoimmunity, and colitis, but its mechanisms of action are unclear. Here, we show that Gimap5 is essential for the inactivation of glycogen synthase kinase-3β (GSK3β) following T cell activation.
Tatsuki Ogasawara et al.
Scientific reports, 7(1), 8630-8630 (2017-08-19)
Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials. One practical issue is graft survival following transplantation. Although a pro-survival cocktail with Matrigel has
商品
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
培养和表征CSC群体的癌症干细胞培养基、球状体培养板和癌症干细胞标志物。
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
相关内容
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门