B1651
缓激肽片段 1-7
≥97% (HPLC)
别名:
1-7-Bradykinin
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关于此项目
经验公式（希尔记法）:
C35H52N10O9
化学文摘社编号:
分子量:
756.85
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
产品名称
缓激肽片段 1-7, ≥97% (HPLC)
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white
UniProt登记号
储存温度
−20°C
SMILES字符串
NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(O)=O
InChI
1S/C35H52N10O9/c36-22(10-4-14-39-35(37)38)31(50)44-16-6-12-26(44)33(52)43-15-5-11-25(43)30(49)40-19-28(47)41-23(18-21-8-2-1-3-9-21)29(48)42-24(20-46)32(51)45-17-7-13-27(45)34(53)54/h1-3,8-9,22-27,46H,4-7,10-20,36H2,(H,40,49)(H,41,47)(H,42,48)(H,53,54)(H4,37,38,39)
InChI key
CRROPKNGCGVIOG-UHFFFAOYSA-N
基因信息
rat ... Nppa(24602)
Amino Acid Sequence
Arg-Pro-Pro-Gly-Phe-Ser-Pro
一般描述
缓激肽片段1-7（BK-(1-7)）是一种内源性肽，存在于血浆中。
应用
缓激肽片段1-7已被用作基质辅助激光解吸电离飞行时间质谱法（MALDI-TOF MS）蛋白质斑点分析中的外部校准物/标准品。
缓激肽片段1-7用于激肽酶的特异性和动力学研究。
生化/生理作用
缓激肽（BK）是一种促炎介质和神经介质。它可以调节多种血管和肾脏功能。缓激肽（BK）在诱导血管通透性和有丝分裂中起关键作用。它有助于在炎症和癌症组织中释放一氧化氮。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
L Germain et al.
Journal of neuroimmunology, 13(2), 135-142 (1986-12-01)
The pathology of acute experimental allergic encephalomyelitis is characterized by perivascular cellular infiltrates in the central nervous system. Our hypothesis is that this immuno-pharmacological process can activate the circulating and tissular kallikrein-kinin systems. We studied 21 New Zealand rabbits inoculated
L Germain et al.
Journal of the neurological sciences, 83(2-3), 211-217 (1988-02-01)
Experimental allergic encephalomyelitis (EAE) is a delayed cell-mediated autoimmune reaction to myelin basic protein. The neuropathology of this acute inflammatory process is characterized by cellular infiltration of the perivascular nervous parenchyma which increases the blood-brain barrier permeability. There is good
M Simmaco et al.
Biochimica et biophysica acta, 1033(3), 318-323 (1990-03-26)
The peptide fraction extracted by methanol from the skin of Rana esculenta, a species widely distributed in Western Europe, was investigated. The pharmacological activity found in the extract is attributable to the presence of authentic bradykinin, together with a shorter
Darren Greetham et al.
Proteomics, 4(7), 1989-1995 (2004-06-29)
Phage display techniques using random peptide interactions have supported the role of mammalian glutathione transferase (GST) as part of a signalling pathway for both oxidative stress and an apoptosis pathway. Little is known about the interaction of nonmammalian GST with
Laura M Jones et al.
Journal of proteome research, 9(6), 2871-2881 (2010-04-16)
The insulin/insulin-like growth factor-1 (IGF-1) signaling system is a public regulator of aging in the model animals Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus. For the first time, proteomic analyses of the environmentally resistant and 'nonaging' C. elegans dauer stage
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