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Merck
CN

B1422

B-Trisaccharide

别名:

α-D-Gal-(1→3)-(α-L-Fuc-[1→2])-D-Gal, Blood group B trisaccharide

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关于此项目

经验公式（希尔记法）:
C18H32O15
化学文摘社编号:
49777-14-2
分子量:
488.44
UNSPSC Code:
12352201
PubChem Substance ID:
329773186
MDL number:
MFCD01311891

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InChI

1S/C18H32O15/c1-4-7(21)10(24)12(26)17(29-4)33-15-14(9(23)6(3-20)30-16(15)28)32-18-13(27)11(25)8(22)5(2-19)31-18/h4-28H,2-3H2,1H3/t4-,5+,6+,7+,8-,9-,10+,11-,12-,13+,14-,15+,16?,17-,18+/m0/s1

SMILES string

C[C@@H]1O[C@@H](O[C@H]2C(O)O[C@H](CO)[C@H](O)[C@@H]2O[C@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@@H]1O

InChI key

XNBZPOHDTUWNMW-OUUCXATCSA-N

assay

≥95% (H-NMR)

form

solid

storage temp.

2-8°C

Quality Level

200

Application

Blood group B trisaccharide may be used to isolate, identify and characterize blood group trisaccharide specific lectins and ligands such as Langerin and MOA (Marasmius oreades agglutinin).

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBR4156V
SLBQ9123V
029K1572
104K0828
028H1177

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N O Seto et al.
European journal of biochemistry, 234(1), 323-328 (1995-11-15)
A 1034-bp synthetic gene encoding the human blood group B glycosyltransferase, which catalyzes the transfer of galactose from UDP-Gal to Fuc alpha(1-2)Gal beta-OR to give the blood group B determinant Gal alpha(1-3)[Fuc alpha(1-2)]Gal beta-OR (where R is a glycoprotein or
L Rydberg et al.
Sub-cellular biochemistry, 32, 107-125 (1999-07-07)
alpha-Gal terminated saccharides are present on the cell surface both as glycolipids and glycoproteins in all mammals except Old World monkeys and humans. The structural diversity among identified saccharides terminated by this epitope in animal tissues is steadily increasing. The
Ming Tan et al.
PloS one, 4(4), e5058-e5058 (2009-04-02)
Human noroviruses are the major viral pathogens of epidemic acute gastroenteritis. These genetically diverse viruses comprise two major genogroups (GI and GII) and approximately 30 genotypes. Noroviruses recognize human histo-blood group antigens (HBGAs) in a diverse, strain-specific manner. Recently the
Michiel van der Vlist et al.
Immunology and cell biology, 88(4), 410-415 (2010-03-24)
Langerhans cells (LC) are the first dendritic cells (DC) to encounter pathogens entering the body via mucosa or skin. Equipped with pattern recognition receptors (PRR), LC are able to detect and respond to these pathogens. An important PRR, in human
Hadar Feinberg et al.
Journal of molecular biology, 405(4), 1027-1039 (2010-11-30)
Langerin mediates the carbohydrate-dependent uptake of pathogens by Langerhans cells in the first step of antigen presentation to the adaptive immune system. Langerin binds to an unusually diverse number of endogenous and pathogenic cell surface carbohydrates, including mannose-containing O-specific polysaccharides
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商品

Review of O-Linked Glycoproteins

O-Linked glycoproteins are usually large proteins with a molecular mass of >200 kDa. Glycosylation generally occurs in high-density clusters and may represent as much as 50-80% of the overall mass.

O-连接糖蛋白回顾

O-连接糖蛋白通常是分子量>200kDa的大蛋白。糖基化通常发生在高密度簇上，并可占总量的50-80%。

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