所有图片(1)
About This Item
经验公式(希尔记法):
C16H15F3N2O4
CAS号:
分子量:
356.30
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥97.5% (HPLC)
表单
powder
颜色
yellow to dark yellow
mp
168-170 °C
溶解性
DMSO: 20 mg/mL
methanol and ethanol: 63 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
CC1=C(C(OC)=O)C(C2=CC=CC=C2C(F)(F)F)C([N+]([O-])=O)=C(C)N1
InChI
1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3
InChI key
ZFLWDHHVRRZMEI-UHFFFAOYSA-N
基因信息
rat ... Cacna1c(24239)
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应用
(±)-Bay K8644已被用作中间神经元中电压敏感型钙通道(VSCC)、人胚肾293细胞中L型钙通道(LTCC)和内脏神经元(viscerofugal neuron)的激动剂。
生化/生理作用
(±)-Bay K8644是1,4-二氢吡啶(DHP)衍生物,也是L型Ca2+ 通道的激动剂。但是,其′对映体(-)-BAY k8644 和 (+)-BAY k8644对于Ca2 +通道有相反的功能,分别作为高效激动剂和低效拮抗剂。(±)-Bay K8644 增加Ca2+的流入量,特别是在电压门控钙通道中。它收缩血管,并使心脏收缩。
增加Ca2+的流入量,特别是在电压门控钙通道中。
警示用语:
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
The calcium channel agonist BAY k 8644 reduces ethanol intake and preference in alcohol-preferring AA rats
de Beun R, et al.
Psychopharmacology, 127(1-2), 302-310 (1996)
Spectrum of Cav1. 4 dysfunction in congenital stationary night blindness type 2
Burtscher V, et al.
Biochimica et Biophysica Acta, 1838(8), 2053-2065 (2014)
Diego Santos de Souza et al.
European journal of pharmacology, 859, 172488-172488 (2019-06-25)
Cardiac arrhythmias are among the most important pathologies that lead to sudden death. The discovery of new therapeutic options against arrhythmias with low adverse effects is of paramount importance. Farnesol is found in essential oils with antioxidant, anti-inflammatory and cardioprotective
CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms.
Bamgboye, et al.
The Journal of General Physiology, 154 (2023)
Opposing actions of Bay K 8644 enantiomers on calcium current, prolactin secretion, and synthesis in pituitary cells
Enyeart JJ, et al.
Molecular Endocrinology, 4(5), 727-735 (1990)
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