推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
46 kDa
种属反应性
guinea pig, rabbit, dog, bovine, horse, human, rat, mouse
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... EGLN1(54583)
一般描述
EGL-9 family hypoxia-inducible factor 1 (EGLN1) is a protein that catalyzes 4-hydroxyproline formation in hypoxia-inducible factor (HIF) alpha proteins. Studies have reported that EGLN1 reacts with nitric oxide and modulates hypoxic responses. EGLN1 polymorphisms have been linked to high altitude sickness.
Rabbit Anti-EGLN1 antibody recognizes canine, human, mouse, rat, and zebrafish EGLN1.
Rabbit Anti-EGLN1 antibody recognizes canine, human, mouse, rat, and zebrafish EGLN1.
免疫原
Synthetic peptide directed towards the C terminal region of human EGLN1
应用
Rabbit Anti-EGLN1 antibody is suitable for western blot applications at a concentration of 1.25 μg/ml.
生化/生理作用
EGLN1 has a role in the regulation of hypoxia-inducible factor. It is not affected by overexpression or downregulation of HIF-2alpha.
序列
Synthetic peptide located within the following region: QPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Norman E Buroker et al.
Blood cells, molecules & diseases, 49(2), 67-73 (2012-05-19)
High altitude sickness (HAS) occurs among humans visiting or inhabiting high altitude environments. Genetic differences in the EPAS1 and EGLN1 genes have been found between lowland (Han) and highland (Tibetan) Chinese. Three SNPs within EPAS1 and EGLN1 were evaluated in
Rasheduzzaman Chowdhury et al.
Journal of molecular biology, 410(2), 268-279 (2011-05-24)
The hypoxic response in animals is mediated via the transcription factor hypoxia-inducible factor (HIF). An oxygen-sensing component of the HIF system is provided by Fe(II) and 2-oxoglutarate-dependent oxygenases that catalyse the posttranslational hydroxylation of the HIF-α subunit. It is proposed
Shilpi Aggarwal et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(44), 18961-18966 (2010-10-20)
It is being realized that identification of subgroups within normal controls corresponding to contrasting disease susceptibility is likely to lead to more effective predictive marker discovery. We have previously used the Ayurvedic concept of Prakriti, which relates to phenotypic differences
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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