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安全信息

AV32342

Sigma-Aldrich

Anti-PSMD4 (AB2) antibody produced in rabbit

IgG fraction of antiserum

别名:

Anti-Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

偶联物

unconjugated

抗体形式

IgG fraction of antiserum

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

41 kDa

种属反应性

horse, bovine, human, mouse, sheep, rabbit, dog, rat, guinea pig

浓度

0.5 mg - 1 mg/mL

技术

western blot: suitable

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

基因信息

human ... PSMD4(5710)

一般描述

PSDM4 is the non-ATPase subunit of the proteasomal 19S regulatory complex that is involved in proteasome-substrate identification. Porcine fertilization studies have reported that PSMD4 regulates sperm-zona pellucida (ZP) penetration. Furthermore, pharmacogenomic analyses have revealed that high expression of PSDM4 is linked to adverse clinical outcomes in myeloma patients undergoing bortezomib treatment.
Rabbit Anti-PSMD4 (AB1) antibody recognizes canine, human, mouse, rat, pig, bovine, chicken, and rabbit PSMD4.

免疫原

Synthetic peptide directed towards the N terminal region of human PSMD4

应用

Rabbit Anti-PSMD4 (AB2) antibody can be used for western blot applications at a concentration of 0.3μg/ml.

生化/生理作用

PSMD4 encodes one of the non-ATPase subunits of the 19S regulator lid which is part of a multicatalytic proteinase complex of the 26S proteasome.

序列

Synthetic peptide located within the following region: VAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDII

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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John D Shaughnessy et al.
Blood, 118(13), 3512-3524 (2011-06-02)
Gene expression profiling (GEP) of purified plasma cells 48 hours after thalidomide and dexamethasone test doses showed these agents' mechanisms of action and provided prognostic information for untreated myeloma patients on Total Therapy 2 (TT2). Bortezomib was added in Total
Young-Joo Yi et al.
Cell and tissue research, 341(2), 325-340 (2010-06-08)
Proteolysis of ubiquitinated sperm and oocyte proteins by the 26S proteasome is necessary for the success of mammalian fertilization, including but not limited to acrosomal exocytosis and sperm-zona pellucida (ZP) penetration. The present study examined the role of PSMD4, an
Kihyun Pyun et al.
Pharmacology, biochemistry, and behavior, 124, 278-283 (2014-07-06)
Primary headache disorders, including migraine, are thought to be mediated by prolonged nociceptive activation of the trigeminal nucleus caudalis (TNC), but the precise mechanisms are poorly understood. Our past studies demonstrated that sigma-1 receptors (Sig-1R) facilitate spinal nociceptive transmission in

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