A9376
腺苷 2′:3′-循环磷酸钠盐 钠盐
≥93%, synthetic (organic), powder
别名:
2′,3′-循环磷酸钠盐
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关于此项目
线性分子式:
C10H11N5O6PNa
化学文摘社编号:
分子量:
351.19
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
EC Number:
253-328-3
MDL number:
产品名称
腺苷 2′:3′-循环磷酸钠盐 钠盐, ≥93%
SMILES string
[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H]4OP([O-])(=O)O[C@@H]34
InChI
1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7-6(4(1-16)19-10)20-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
InChI key
VSDSIACSNXHGOV-MCDZGGTQSA-M
biological source
synthetic (organic)
assay
≥93%
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
相关类别
Application
腺苷2′:3′-环单磷酸钠盐已用于亲和纯化应用的裂解缓冲液，同时用于微量热泳动测量。此外，它还被用于黄粉虫管的电生理研究。
Biochem/physiol Actions
腺苷2′,3′-环单酸酯(2′,3′-cAMP) 被视为腺苷的细胞外来源。 2′,3′-cAMP作为损伤响应在细胞外释放。2′,3′-cAMP可用于研究其降解酶在独特生物活性背景下的分布和特异性。2′,3′-cAMP也可用于研究诱导细胞凋亡的线粒体通透性过渡水平。2′,3′-cAMP被转换为2′-AMP和3′-AMP，从而通过A2B受体抑制肾小球前血管平滑肌细胞和肾小球系膜细胞的增殖。
Disclaimer
警告：请勿与普通的腺苷2′(3′)-单磷酸酯（混合异构体）混淆。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
R P Ballestero et al.
The Journal of biological chemistry, 272(17), 11479-11486 (1997-04-25)
Biochemical characterization of changes in gene expression that accompany optic nerve regeneration has led to the identification of proteins that may play key roles in the regeneration process. In this report, a cDNA encoding gRICH70, a novel isoform of the
Jin Ren et al.
The Journal of pharmacology and experimental therapeutics, 328(3), 855-865 (2008-11-27)
We recently developed a sensitive assay for 3',5'-cAMP using high-performance liquid chromatography-tandem mass spectrometry. Using this assay, we investigated the release of 3',5'-cAMP from isolated, perfused rat kidneys. To our surprise, we observed a dominant chromatographic peak that was because
Interaction of 2′, 3′-cAMP with Rbp47b plays a role in stress granule formation.
Kosmacz M, et al.
Plant Physiology, pp-00285 (2018)
S G Srivatsan et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 8(22), 5184-5191 (2003-03-05)
We have synthesized and characterized novel, copper-metalated, polymeric templates that contain adenine nucleobases. These promote hydrolysis of non-natural and natural phosphate ester substrates in a highly efficient and catalytic fashion. The crystal structure of the cooper-containing adenylated monomer reveals the
Edwin K Jackson et al.
The Journal of biological chemistry, 284(48), 33097-33106 (2009-10-06)
We discovered that renal injury releases 2',3'-cAMP (positional isomer of 3',5'-cAMP) into the interstitium. This finding motivated a novel hypothesis: renal injury leads to activation of an extracellular 2',3'-cAMP-adenosine pathway (i.e. metabolism of extracellular 2',3'-cAMP to 3'-AMP and 2'-AMP, which
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