A9187
Adenosine 5′-triphosphate 镁盐
≥95%, bacterial, powder
别名:
ATP 镁盐
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关于此项目
经验公式（希尔记法）:
C10H16N5O13P3 · xMg2+
化学文摘社编号:
分子量:
507.18 (free acid basis)
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
MDL number:
产品名称
Adenosine 5′-triphosphate 镁盐, ≥95%, bacterial
SMILES string
[Mg].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C3O
InChI
1S/C10H16N5O13P3.Mg.2H/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;
InChI key
CPGAIACWYFBIFN-UHFFFAOYSA-N
biological source
bacterial
assay
≥95%
form
powder
solubility
H2O: 50 mg/mL
storage temp.
−20°C
Quality Level
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Application
腺苷5′-三磷酸镁盐已可用于：
- 作为细胞内Ca2+ 保留测定和荧光广域成像分析的补充剂
- 作为甲烷磺酸钾内溶物的一种成分，用于皮层神经元的 体外 电生理研究
- 作为细胞内电位溶液中起作用的组分
Biochem/physiol Actions
P2 嘌呤能激动剂；增加 Ca2+-激活的 K+ 通道的活性；ATP-依赖酶系统的底物
腺苷5γ-三磷酸腺苷(ATP)是体内能量储存和代谢的中心成分。 ATP应用于许多细胞过程、呼吸、生物合成反应、运动和细胞分裂。ATP是许多激酶的底物，这些激酶参与细胞信号和腺苷酸环化酶(s)，产生第二个信使 cAMP。 ATP提供代谢能量来驱动代谢泵。 ATP在一系列酶促反应中充当辅酶。
signalword
Warning
hcodes
Hazard Classifications
STOT SE 2
target_organs
Eyes,Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Lea Wagmann et al.
Archives of toxicology, 92(9), 2875-2884 (2018-08-08)
Transporter-mediated drug-drug interactions (DDI) may induce adverse clinical events. As drugs of abuse (DOA) are marketed without preclinical safety studies, only very limited information about interplay with membrane transporters are available. Therefore, 13 DOA of various classes were tested for
Spatial separation of mitochondrial calcium uptake and extrusion for energy-efficient mitochondrial calcium signaling in the heart.
De La Fuente S, et al.
Cell reports, 24(12), 3099-3107 (2018)
Hyun Jong Kim et al.
European journal of pharmacology, 791, 686-695 (2016-10-30)
Pyrazole derivatives were originally suggested as selective blockers of the transient receptor potential cation 3 (TRPC3) and channel. In particular, pyr3 and 10 selectively inhibit TRPC3, whereas pyr2 (BTP2) and 6 inhibit ORAI1. However, their effects on background K+ channel
Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.
Fenske S, et al.
Nature Protocols, 11(1), 61-61 (2016)
A subpopulation of striatal neurons mediates Levodopa-induced dyskinesia.
Girasole AE, et al.
Neuron, 97(4), 787-795 (2018)
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