A7219
L-天冬氨酸
from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
别名:
(S)-(+)-氨基琥珀酸, (S)-氨基丁二酸
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关于此项目
线性分子式:
HO2CCH2CH(NH2)CO2H
化学文摘社编号:
分子量:
133.10
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-291-6
MDL number:
Beilstein/REAXYS Number:
1723530
产品名称
L-天冬氨酸, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
InChI key
CKLJMWTZIZZHCS-REOHCLBHSA-N
InChI
1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
SMILES string
N[C@@H](CC(O)=O)C(O)=O
biological source
non-animal source
agency
meets EP testing specifications
meets USP testing specifications
assay
98.5-101.0%
form
powder
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
white to off-white
mp
>300 °C (dec.) (lit.)
solubility
1 M HCl: 100 mg/mL
Quality Level
Gene Information
human ... CA1(759), CA2(760)
rat ... Grin2a(24409)
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Application
L-天冬氨酸已用作：
- 阿斯巴甜（ASP）代谢物(ASP)，以测定乳鼠海马匀浆中乙酰胆碱酯酶（AChE）的活性
- 印染趋化受体，以利用高通量技术筛选趋化受体并验证与表面等离子体共振（SPR）和核磁共振（NMR）的相互作用
- 杜皮克氏′改良爱哥尔氏培养基′（DMEM）的补充剂，以用于各种培养细胞系的补充试验
Biochem/physiol Actions
快速兴奋突触的主要神经递质。
General description
天冬氨酸（ASP）是一种非必需氨基酸，由哺乳动物自然产生。ASP是蛋白质的20个基本氨基酸之一，并有一个字母代码D。L-天冬氨酸可通过使用天冬氨酸酶的酶促过程进行工业化生产。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Aspartic acid
Johnson EC
reference module in biomedical sciences (2017)
Amino acid production
Eggeling L and Sahm H
Comprehensive Biotechnology (2011)
Christopher J Day et al.
Methods in molecular biology (Clifton, N.J.), 1512, 51-63 (2016-11-26)
Despite many years of research into bacterial chemotaxis, the only well characterized system to date is that of E. coli. Even for E. coli, the direct ligand binding had been fully characterized only for aspartate and serene receptors Tar and
Hongyu Ding et al.
Science advances, 7(47), eabk1023-eabk1023 (2021-11-18)
[Figure: see text].
Thomas Bertero et al.
Cell metabolism, 29(1), 124-140 (2018-10-09)
Dysregulation of extracellular matrix (ECM) deposition and cellular metabolism promotes tumor aggressiveness by sustaining the activity of key growth, invasion, and survival pathways. Yet mechanisms by which biophysical properties of ECM relate to metabolic processes and tumor progression remain undefined.
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