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Merck
CN
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文件

A6779

Sigma-Aldrich

高碘酸氧化腺苷 5′-三磷酸 钠盐

≥97%

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别名:
oATP, 腺苷 5′-三磷酸-2′,3′-二醛
经验公式（希尔记法）:
C10H14N5O13P3
CAS号:
71997-40-5
分子量:
505.17
MDL编号:
MFCD00056956
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
24891137
NACRES:
NA.51

生物来源

bacterial (corynebacterium sp)

质量水平

200

检测方案

≥97%

形式

powder

储存温度

−20°C

SMILES字符串

[Na].Nc1ncnc2n(cnc12)[C@H](O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=O)C=O

InChI

1S/C10H14N5O13P3.Na.H/c11-9-8-10(13-4-12-9)15(5-14-8)7(2-17)26-6(1-16)3-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h1-2,4-7H,3H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/t6-,7+;;/m0../s1

InChI key

IHQATUPGVKMGLT-AUCRBCQYSA-N

一般描述

腺苷-5′-三磷酸-2′，3′-二醛是二醛的一种衍生物。

应用

腺苷-5′-三磷酸，高碘酸氧化钠盐已被用于：
  • 作为嘌呤能受体的拮抗剂（P2×7抑制P2×7通路）
  • 作为通过Ca2+评估P2x7-R活性的非特异性激动剂
  • 评估细胞内ATP水平升高的生理意义
  • 评估Flcn缺陷细胞中用于破骨细胞生成的P2rx7表达升高的生理意义

生化/生理作用

腺苷-5′-三磷酸-2′，3′-二醛被认为是P2×7受体的一种抑制剂。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Daniela Gentile et al.
Frontiers in pharmacology, 8, 638-638 (2017-09-29)
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Science signaling, 1(39), ra6-ra6 (2008-10-02)
T cell receptor (TCR) stimulation results in the influx of Ca(2+), which is buffered by mitochondria and promotes adenosine triphosphate (ATP) synthesis. We found that ATP released from activated T cells through pannexin-1 hemichannels activated purinergic P2X receptors (P2XRs) to
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Scientific reports, 9(1), 8617-8617 (2019-06-15)
Adenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory mechanisms of the purinergic receptor
Xuejing Cui et al.
Small (Weinheim an der Bergstrasse, Germany), 12(43), 5998-6011 (2016-09-21)
Exocytosis of single-walled carbon nanotubes (SWCNTs) determines therapeutic efficiency and toxicity of nanoproducts but its underlying mechanism remains elusive. In this study, it is found that the exocytosis mechanism of SWCNTs is mediated mainly through the activation of P2X7 receptor
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