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安全信息

A6778

Sigma-Aldrich

血管紧张素转换酶 来源于兔肺

≥2.0 units/mg protein (modified Warburg-Christian)

别名:

ACE, 肽基-二肽水解酶, 肽基-二肽酶 A

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About This Item

CAS号:
9015-82-1
EC 号:
3.4.15.1 (BRENDA, IUBMB)
MDL编号:
MFCD00130325
UNSPSC代码:
12352204
eCl@ss:
42010109
NACRES:
NA.32

形式

lyophilized powder

质量水平

200

比活

≥2.0 units/mg protein (modified Warburg-Christian)

运输

dry ice

储存温度

−20°C

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一般描述

血管紧张素转换酶(ACE)是一种二肽基羧肽酶，存在于具有锌结合基序HEXXH的体细胞和睾丸亚型中。ACE通过肾素-血管紧张素系统调节血压。ACE通过将血管紧张素I转化为一种关键的血管收缩剂血管紧张素II，并抑制一种有效的血管舒张剂缓激肽，从而提高血压。抑制血管紧张素转换酶(ACE)是一种有针对性的高血压治疗策略。临床应用的ACE合成抑制肽包括卡托普利、依那普利和赖诺普利。目前，正在从天然食物来源 或植物来源的酚类化合物中开发抑制ACE的多肽。ACE通过释放精子膜中与糖基磷脂酰肌醇(GPI)结合的蛋白，在受精过程中发挥重要作用。

应用

兔肺血管紧张素转换酶已应用于:
  • 采用高效液相色谱法测定蛋清蛋白水解物对ACE活性的抑制作用
  • 以希波瑞尔-L-组氨酸-L-亮氨酸(HHL)为底物，分别采用反相高效液相色谱(RP-HPLC)3和HPLC法 测定荔枝果皮 和熟鸡胸肉 对血管紧张素转换酶(ACE)的抑制作用
  • 提高一些细胞系在 体外 释放GPI锚定蛋白，如HeLa, HEK293和 体内 小鼠精子。

生化/生理作用

去除易受影响的底物（如紧张素 I 和缓激肽）中的 C-端二肽。

质量

可能含微量氯化钠。

单位定义

在pH为8.3，温度为37°C的条件下，在50mM HEPES和300mM NaCl中，一个单位每分钟可将1.0μmole的马尿酰组氨酰亮氨酸转化成马尿酸。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H334

预防措施声明

P261 - P284 - P501

危险分类

Resp. Sens. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Are there any other known inhibitors of rabbit lung Angiotensin Converting Enzyme (ACE), Product A6778?

    Idrapril, the prototype of a new class of angiotensin converting enzyme (ACE) inhibitors, competitively inhibits, with nanomolar apparent Ki, the hydrolysis of hippuryl-glycyl-glycine by rabbit lung ACE.  Kinetic Ki and kon and koff values were 470 pM, 3.0±1.5×106 M-1sec-1 and 1.4±0.3×10-3 sec-1, respectively.  Reference: Biochemical Pharmacology, 45(6), 1358-1362 (1993).

  6. What is the medical significance of Angiotensin Converting Enzyme (ACE), Product A6778?

    Angiotensin-converting enzyme (ACE) produces angiotensin II, a substance that affects the cardiovascular system in numerous ways, including narrowing of blood vessels. This narrowing can cause high blood pressure and cause the heart to work harder.  ACE inhibitors treat a variety of conditions, such as high blood pressure, scleroderma and migraines. (Mayo Clinic)

  7. What is the effect of bleomycin on Angiotensin Converting Enzyme (ACE) activity in vivo?

    Bleomycin causes a marked reduction in rabbit lung ACE activity. Reference: Cancer Research, 40, 3621-3626, (1980).

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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The 2002-3 pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV) was one of the most significant public health events in recent history. An ongoing outbreak of Middle East respiratory syndrome coronavirus suggests that this group of viruses remains a
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