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Merck
CN

A6376

N-乙酰基-L-色氨酸

≥99% (TLC), suitable for ligand binding assays

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关于此项目

经验公式(希尔记法):
C13H14N2O3
化学文摘社编号:
分子量:
246.26
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
EC Number:
214-935-9
MDL number:
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产品名称

N-乙酰基-L-色氨酸,

SMILES string

CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O

InChI

1S/C13H14N2O3/c1-8(16)15-12(13(17)18)6-9-7-14-11-5-3-2-4-10(9)11/h2-5,7,12,14H,6H2,1H3,(H,15,16)(H,17,18)/t12-/m0/s1

InChI key

DZTHIGRZJZPRDV-LBPRGKRZSA-N

assay

≥99% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

storage temp.

2-8°C

Quality Level

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Biochem/physiol Actions

N-乙酰基-L-色氨酸(NAT, Ac-Trp-OH)可用作底物PNK1速激肽受体拮抗剂。N-乙酰基-L-色氨酸也作为一种竞争性抑制剂,用于鉴定、区分和表征色氨酸酶。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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New tryptophanase inhibitors: towards prevention of bacterial biofilm formation.
Scherzer R, Gdalevsky GY, et al.
Journal of Enzyme Inhibition, 24, 350-355 (2009)
James J Donkin et al.
Journal of neurotrauma, 28(2), 217-224 (2010-12-24)
Previous studies have demonstrated that the compound N-acetyl-L-tryptophan (NAT) reduces brain edema and improves functional outcome following traumatic brain injury (TBI). In this study we examined whether this effect was mediated via the neurokinin-1 receptor, and whether there was an
Jan Stange et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 17(6), 705-709 (2011-05-28)
Liver failure is associated with an accumulation of toxic molecules that exert an affinity to albumin. Some of them have vasoactive activity. So far, albumin has been used as a plasma expander to improve the available circulating blood volume. However
Christine M Barry et al.
Brain research, 1389, 143-151 (2011-03-08)
Raised intracranial pressure (ICP) following SAH predicts poor outcome and is due to hemorrhage volume and possibly, brain edema, hydrocephalus and increased volume of circulating intracranial blood. Interventions that reduce edema may therefore reduce ICP and improve outcome. The neuropeptide
Emma Thornton et al.
PloS one, 7(4), e34138-e34138 (2012-04-10)
Neuroinflammation and blood brain barrier (BBB) dysfunction have been implicated in the pathogenesis of Parkinson's disease (PD). The neuropeptide substance P (SP) is an important mediator of both neuroinflammation and BBB dysfunction through its NK1 receptor in a process known

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