A6218
Anti-ATM antibody, Mouse monoclonal
clone SYML6A10, purified from hybridoma cell culture
别名:
Monoclonal Anti-ATM antibody produced in mouse, Anti-Ataxia-Telangiectasia Mutated
产品名称
Anti-ATM antibody, Mouse monoclonal, clone SYML6A10, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
SYML6A10, monoclonal
form
buffered aqueous solution
mol wt
antigen ~350 kDa
species reactivity
human
technique(s)
immunocytochemistry: suitable
microarray: suitable
western blot: 1-2 μg/mL using total cell extract from a G-361 (human melanoma) cell line
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ATM(472)
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Application
Mouse Monoclonal Anti-ATM antibody can be used for western blot assays at 1-2μg/ml using G-361 cell extracts. The antibody can also be used for immunocytochemistry and microarray applications.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Ataxia-Telangiectasia Mutated (ATM) is a member of the phosphatidylinositol 3-kinase (PI-3) family of kinases. It is activated in response to DNA damage such as double stranded breaks.
Mouse Monoclonal Anti-ATM antibody binds to human ATM.
Immunogen
synthetic peptide corresponding to the C-terminal region of human ATM with N-terminally added cysteine, conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Jun Yang et al.
Carcinogenesis, 24(10), 1571-1580 (2003-08-16)
Exposure to genotoxic agents is a major cause of human cancer, and cellular responses to genotoxic stress are important defense mechanisms. These responses are very complex, involving many cellular factors that form an extensive signal transduction network. This network includes
Karen S Yee et al.
Cancer research, 72(9), 2206-2217 (2012-03-06)
RASSF1A (Ras association domain containing family 1A), a tumor suppressor gene that is frequently inactivated in human cancers, is phosphorylated by ataxia telangiectasia mutated (ATM) on Ser131 upon DNA damage, leading to activation of a p73-dependent apoptotic response. A single-nucleotide
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