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安全信息

A6150

Sigma-Aldrich

α1-抗胰蛋白酶 来源于人类血浆

salt-free, lyophilized powder

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别名:
α1-蛋白酶抑制剂
CAS号:
9041-92-3
EC 号:
232-924-7
MDL编号:
MFCD00130469
UNSPSC代码:
12352202
NACRES:
NA.77

生物来源

human plasma

质量水平

200

形式

salt-free, lyophilized powder

浓度

≥60% (biuret)

技术

inhibition assay: suitable

UniProt登记号

P01009
P08246

储存温度

2-8°C

基因信息

human ... ELA2(1991) , ELANE(1991) , SERPINA1(5265)

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生化/生理作用

丝氨酸蛋白酶抑制剂；抑制胰蛋白酶、胰凝乳蛋白酶和胰腺和粒细胞弹性蛋白酶、以及顶体酶。有效浓度与蛋白酶等摩尔。遗传性 α1-抗胰蛋白酶缺乏的影响和某些自身免疫状态是由体内不受控制的蛋白水解引起的。Direct α1-抗胰蛋白酶替代疗法在1型糖尿病的动物模型中具有应用前景。
≤10 mg可抑制1.0 mg 蛋白活性10,000 BAEE/mg的胰蛋白酶。≤10 mg可抑制约1.0 mg 40-50 BTEE/mg的糜蛋白酶。

注意

含有0.01％NaN3的水溶液可稳定几个月。溶液可在−80 °C下储存，但不应重新冷冻。其在pH 5.5以下不稳定。其可由一些非丝氨酸蛋白酶，以及氧化活性位点的甲硫氨酸残基进行灭活。

制备说明

色谱法制备且部分纯化。

免责声明

仅供研究使用。本品在法国的科研应用受到监管，包括用于进口和出口活动（法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2）。如《公共卫生法典》所述，购买者（即最终用户）需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the carbohydrate content of human alpha-1-Antitrypsin?

    We have found the information on alpha-1-antitrypsin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.The alpha-1-antitrypsin is 12 percent carbohydrate, citing K. Heide and H.G. Schwick, Chemistry and Significance of the Carbohydrate Moieties of Human Serum Glycoproteins, Angew. Chem., Int. Ed. Eng., 12, 721-733 (1973).The table also gives information on the percentage of each type of monosaccharide that is present.

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