ELANE
elastase, neutrophil expressed
别名:
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
物种:
Human ELANE (1991), Mouse Elane (50701), Rat Elane (299606), sheep ELANE (101110841), cow ELANE (100126050), dog ELANE (442980), domestic cat ELANE (100301482), Horse ELANE (100462967), domestic guinea pig Elane (100724414)
UniProtKB ID:
基因ID:
- Human(1991) Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
- Mouse(50701) elastase, neutrophil expressed
- Rat(299606) elastase, neutrophil expressed
- sheep(101110841) elastase, neutrophil expressed
- cow(100126050) elastase, neutrophil expressed
- dog(442980) elastase, neutrophil expressed
- domestic cat(100301482) elastase, neutrophil expressed
- Horse(100462967) elastase, neutrophil expressed
- domestic guinea pig(100724414) elastase, neutrophil expressed
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
货号
说明
物种反应性
应用
Anti-Elane Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Anti-Neutrophil Elastase Antibody, clone AHN-10, clone AHN-10, from mouse,
物种反应性
human
应用
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
radioimmunoassay
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
radioimmunoassay
中性粒细胞弹性蛋白酶抗体，兔单克隆, clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody,
物种反应性
human
应用
immunohistochemistry
Anti-Neutrophil Elastase (ELANE) Antibody, clone 8X4E6, Rabbit Monoclonal, ,
物种反应性
mouse
应用
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Proteins
esiRNA
货号
说明
物种