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Merck
CN

A3734

1-氮杂坎帕罗酮

≥97% (HPLC), glycogen synthase kinase 3β (GSK3β) inhibitor, powder

别名:

9-溴-7，12-二氢-吡啶并[3′，2′:2，3]吖庚因并[4，5-b]吲哚-6（5H）-酮

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关于此项目

经验公式（希尔记法）:
C15H10BrN3O
化学文摘社编号:
676596-65-9
分子量:
328.16
UNSPSC Code:
12352200
PubChem Substance ID:
329770845
NACRES:
NA.77
MDL number:
MFCD09037522

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产品名称

1-氮杂坎帕罗酮, ≥97% (HPLC)

SMILES string

O=C1CC2=C(NC3=C2C=C(Br)C=C3)C4=C(C=CC=N4)N1

InChI key

NTSBZVCEIVPKBJ-UHFFFAOYSA-N

InChI

1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)

assay

≥97% (HPLC)

form

powder

storage condition

protect from light

color

gray-brown

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

1-Azakenpaullone 是一种细胞渗透性、有效的选择性糖原合酶激酶 3 抑制剂3β （GSK3β）与 CDK 的交叉反应性低 100 倍。1-Azakenpaullone 可与 BIO 和 CHIR99021 一起用作 GSK3 抑制的“金标准”。
1-Azakenpaullone 是一种细胞渗透性、有效的选择性糖原合酶激酶 3β （GSK3β）抑制剂，与 CDK 的交叉反应性低 100 倍。
1-氮杂坎帕罗酮（AZP）可刺激β-连环蛋白相关基因的转录。该化合物能诱导β细胞的增殖和复制。

Disclaimer

空气敏感

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000452945
0000452945
0000241331
0000241331
0000179959

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Charles W Tran et al.
Journal of immunology (Baltimore, Md. : 1950), 199(12), 4056-4065 (2017-11-08)
The decision between T cell activation and tolerance is governed by the spatial and temporal integration of diverse molecular signals and events occurring downstream of TCR and costimulatory or coinhibitory receptor engagement. The PI3K-protein kinase B (PKB; also known as
Combination effects of AHR agonists and Wnt beta-catenin modulators in zebrafish embryos: implications for physiological and toxicological AHR functions
Wincent E, et al.
Toxicology and Applied Pharmacology, 284(2), 163-179 (2015)
Rong Hu et al.
Stem cells translational medicine, 6(1), 121-130 (2017-02-09)
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many malignant and nonmalignant diseases. However, chronic graft-versus-host disease (cGVHD) remains a significant cause of late morbidity and mortality after allogeneic HSCT. cGVHD often manifests as autoimmune syndrome.
Thiranut Jaroonwitchawan et al.
Biochemical and biophysical research communications, 481(1-2), 176-181 (2016-11-07)
Neural crest (NC) is a transient population, arising during embryonic development and capable of differentiating into various somatic cells. The defects of neural crest development leads to neurocristopathy. Several signaling pathways were revealed their significance in NC cell specification. Fibroblast
9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication
Stukenbrock H, et al.
Journal of medicinal chemistry, 51(7), 2196-2207 (2008)
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