所有图片(1)
About This Item
经验公式（希尔记法）:
C15H10BrN3O
CAS号:
分子量:
328.16
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥97% (HPLC)
形式
powder
储存条件
protect from light
颜色
gray-brown
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
O=C1CC2=C(NC3=C2C=C(Br)C=C3)C4=C(C=CC=N4)N1
InChI
1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
InChI key
NTSBZVCEIVPKBJ-UHFFFAOYSA-N
生化/生理作用
1-Azakenpaullone 是一种细胞渗透性、有效的选择性糖原合酶激酶 3 抑制剂3β （GSK3β）与 CDK 的交叉反应性低 100 倍。1-Azakenpaullone 可与 BIO 和 CHIR99021 一起用作 GSK3 抑制的“金标准”。
1-氮杂坎帕罗酮（AZP）可刺激β-连环蛋白相关基因的转录。该化合物能诱导β细胞的增殖和复制。
注意
空气敏感
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication
Stukenbrock H, et al.
Journal of medicinal chemistry, 51(7), 2196-2207 (2008)
Thiranut Jaroonwitchawan et al.
Biochemical and biophysical research communications, 481(1-2), 176-181 (2016-11-07)
Neural crest (NC) is a transient population, arising during embryonic development and capable of differentiating into various somatic cells. The defects of neural crest development leads to neurocristopathy. Several signaling pathways were revealed their significance in NC cell specification. Fibroblast
Rong Hu et al.
Stem cells translational medicine, 6(1), 121-130 (2017-02-09)
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for many malignant and nonmalignant diseases. However, chronic graft-versus-host disease (cGVHD) remains a significant cause of late morbidity and mortality after allogeneic HSCT. cGVHD often manifests as autoimmune syndrome.
Combination effects of AHR agonists and Wnt beta-catenin modulators in zebrafish embryos: implications for physiological and toxicological AHR functions
Wincent E, et al.
Toxicology and Applied Pharmacology, 284(2), 163-179 (2015)
Hiromi Takahashi et al.
Development genes and evolution, 229(2-3), 73-81 (2019-01-12)
Establishment of the body plan of multicellular organisms by the primary body axis determination and cell-fate specification is a key issue in biology. We have examined the mRNA localization of three Wnt pathway components gsk3β, β-catenin, and disheveled and investigated
商品
Glycogen synthase kinase 3 (GSK-3) is a highly conserved family of serine/threonine kinases for over 100 proteins in many pathways. See a list of accepted GSK-3 modulators and related products.
肝醣合成酶激酶3 (GSK-3)是一种高度保守的丝氨酸/苏氨酸激酶家族，适于在多种途径中处理100多种蛋白质。查看允许的GSK-3调节剂和相关产品列表。
实验方案
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