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Merck
CN

A3262

Sigma-Aldrich

腺苷-3′,5′-环单磷酸 三羟甲基氨基甲烷盐

≥97% (HPLC), powder

别名:

cAMP, 环磷腺苷

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About This Item

经验公式(希尔记法):
C10H12N5O6P · C4H11NO3
分子量:
450.34
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51

生物来源

synthetic

质量水平

方案

≥97% (HPLC)

表单

powder

颜色

white

溶解性

H2O: 100 mg/mL

储存温度

−20°C

SMILES字符串

NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O

InChI

1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1

InChI key

CLDDYJFNXTUHIN-MCDZGGTQSA-N

相关类别

一般描述

在存在腺苷酸环化酶的存在下,由ATP合成腺苷3′,5′-环一磷酸(cAMP)。 cAMP主要用作免疫化学检测分析中的标记。胞内cAMP水平控制着免疫和炎症功能。细菌感染可触发胞内cAMP产生。 cAMP水平升高可调节癌细胞中的促分裂原活化蛋白激酶(MAPK) 。cAMP水平改变与白内障和心血管疾病的发病机理有关。 cAMP水平降低会触发糖尿病中胰岛素分泌受损。

应用

腺苷3′,5′-环一磷酸三盐已被用作人类子宫内膜间质细胞 (hESC) 培养和诱导神经干细胞(iNSC)的培养基补充剂。它已用于pink flamindo(红色 cAMP 指示剂)的光谱表征。

生化/生理作用

环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP 是一种重要的第二信使,并且在很多系统中与神经递质或激素诱导的受体激活相关。已有显示,cAMP/PKA 信号通路可抑制细胞增殖,诱导分化并导致细胞凋亡。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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