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Merck
CN

A3145

Sigma-Aldrich

芹菜素

≥97% (TLC), from parsley, powder

别名:

4 & # 8242;,5,7-三羟基黄酮, 5,7-二羟基-2-(4-羟基苯基)-4-苯并吡喃酮

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About This Item

经验公式(希尔记法):
C15H10O5
CAS号:
分子量:
270.24
Beilstein:
262620
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:

生物来源

parsley

方案

≥97% (TLC)

表单

powder

颜色

yellow

mp

>300 °C (lit.)

溶解性

DMSO: 27 mg/mL
1 M KOH: 50 mg/mL

储存温度

−20°C

SMILES字符串

Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

InChI key

KZNIFHPLKGYRTM-UHFFFAOYSA-N

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生化/生理作用

一种植物类黄酮,研究发现它通过在G2/M阶段阻止细胞周期来抑制细胞增殖。通过细胞周期停滞和诱导凋亡来抑制生长似乎与p53的诱导有关。通过抑制蛋白激酶C和由此导致的癌基因表达抑制来抑制PMA介导的肿瘤促进。研究还报道了抑制拓扑异构酶ⅰ催化的脱氧核糖核酸再连接和增强间隙连接细胞间通讯。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number

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Émilie C Lefort et al.
Molecular nutrition & food research, 57(1), 126-144 (2012-12-01)
Apigenin (4',5,7-trihydroxyflavone, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one) is a flavonoid found in many fruits, vegetables, and herbs, the most abundant sources being the leafy herb parsley and dried flowers of chamomile. Present in dietary sources as a glycoside, it is cleaved in the gastrointestinal
Naiara Silva Dourado et al.
Frontiers in aging neuroscience, 12, 119-119 (2020-06-06)
Neurodegenerative disorders (ND) are characterized by the progressive and irreversible loss of neurons. Alzheimer's Disease (AD) is the most incident age-related ND, in which the presence of a chronic inflammatory compound seems to be related to its pathogenesis. Different stimuli
Kaihui Lu et al.
Journal of natural products, 76(4), 672-678 (2013-03-26)
Adipocyte dysfunction is a major cause of obesity, which is associated strongly with many disorders including psychological and medical morbidities, metabolic abnormalities, and cardiovascular diseases as well as a series of cancers. This study investigated the antiadipogenic activity of scutellarin
John Sanseverino et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(1), 122-134 (2008-11-11)
Saccharomyces cerevisiae bioluminescent bioreporter assays were developed previously to assess a chemical's estrogenic or androgenic disrupting potential. S. cerevisiae BLYES, S. cerevisiae BLYAS, S. cerevisiae BLYR, were used to assess their reproducibility and utility in screening 68, 69, and 71
Benjamin Dilberger et al.
Nutrients, 11(8) (2019-08-16)
(1) Background: Polyphenols (PP) play an important role in the prevention of non-communicable diseases and may contribute to healthy aging. To investigate the molecular and cellular aspects of PP metabolites on longevity with a focus on mitochondrial function, we applied

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