A254
AIDA
solid
别名:
1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid, 1-Aminoindan-1, 5-dicarboxylic acid, UPF 523
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关于此项目
经验公式（希尔记法）:
C11H11NO4
化学文摘社编号:
分子量:
221.21
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
产品名称
AIDA, solid
InChI
1S/C11H11NO4/c12-11(10(15)16)4-3-6-5-7(9(13)14)1-2-8(6)11/h1-2,5H,3-4,12H2,(H,13,14)(H,15,16)
SMILES string
NC1(CCc2cc(ccc12)C(O)=O)C(O)=O
InChI key
LSTPKMWNRWCNLS-UHFFFAOYSA-N
form
solid
color
white
solubility
DMSO: 2 mg/mL
Quality Level
Gene Information
human ... GRM1(2911)
rat ... Grm1(24414)
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Biochem/physiol Actions
Selective mGluR1 metabotropic glutamate receptor antagonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
F Moroni et al.
The Journal of pharmacology and experimental therapeutics, 281(2), 721-729 (1997-05-01)
We examined the pharmacological profile of 1-aminoindan-1,5-dicarboxylic acid (AIDA), a rigid (carboxyphenyl)glycine derivative acting on metabotropic glutamate receptors (mGluRs). In cells transfected with mGluR1a, AIDA competitively antagonized the stimulatory responses of glutamate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD] on phosphoinositide hydrolysis (pA2
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