所有图片(4)
别名:
5′-AMP, 5′-腺苷酸, A-5′-P, AMP
经验公式（希尔记法）:
C10H14N5O7P · H2O
CAS号:
分子量:
365.24
Beilstein:
54612
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51
推荐产品
生物来源
yeast
质量水平
检测方案
≥97%
形式
powder
溶解性
1 M NH4OH: soluble 50 mg/mL, clear, colorless
H2O: soluble (with addition of mild alkali)
储存温度
−20°C
SMILES字符串
O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1COP(O)(O)=O.O
InChI
1S/C10H14N5O7P.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);1H2/t4-,6-,7-,10-;/m1./s1
InChI key
ZOEFQKVADUBYKV-MCDZGGTQSA-N
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应用
5′-单磷酸腺苷（5′-AMP）适合用作
- 合成腺苷-5′-磷酰咪唑啉的试剂
- 合成支链多糖的聚合反应中磷酸化酶b的活化剂
- 内源性NMN腺苷酰转移酶（NMNAT，将NMN转化成NAD+）的活性抑制剂
生化/生理作用
5′-单磷酸腺苷（5′-AMP）本身具有许多用途。5′-AMP是一类称为AMP活化蛋白激酶（AMPK）的蛋白激酶的激活剂。AMP可抑制AMPK去磷酸化，促进上游激酶对AMPK磷酸化。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Physical properties and structure of enzymatically synthesized amylopectin analogs
Ciric, Jelena, et al.
Starch/Staerke, 65, 1061-1068 (2013)
Bei Liu et al.
Nature communications, 12(1), 5201-5201 (2021-09-02)
N6-methyladenosine (m6A) is a post-transcriptional modification that controls gene expression by recruiting proteins to RNA sites. The modification also slows biochemical processes through mechanisms that are not understood. Using temperature-dependent (20°C-65°C) NMR relaxation dispersion, we show that m6A pairs with
Marianne Suter et al.
The Journal of biological chemistry, 281(43), 32207-32216 (2006-09-01)
AMP-activated protein kinase (AMPK) is a heterotrimeric protein kinase that is crucial for cellular energy homeostasis of eukaryotic cells and organisms. Here we report on the activation of AMPK alpha1beta1gamma1 and alpha2beta2gamma1 by their upstream kinases (Ca(2+)/calmodulin-dependent protein kinase kinase-beta
Irina S Balan et al.
Brain research, 1316, 112-119 (2009-12-29)
A histo-enzymatic technique for visualizing and quantifying endogenous NAD(H) in brain tissue was developed, based on coupled enzymatic cycling reactions that reduce nitrotetrazolium blue chloride to produce formazan. Conditions were used where the endogenous level of nicotinamide adenine dinucleotides (NAD(H))
Yuanzhong Xu et al.
Biochemical and biophysical research communications, 451(2), 184-189 (2014-07-30)
The melanocortin receptor 4 (MC4R) plays a major role in body weight regulation and its agonist MTII has been widely used to study the role of MC4Rs in energy expenditure promotion and feeding reduction. Unexpectedly, we observed that intraperitoneal (i.p.)
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