生物来源
human
质量水平
检测方案
≥96% (agarose gel electrophoresis)
形式
lyophilized powder
分子量
monomer calculated mol wt 66478 Da
技术
ELISA: suitable
tissue culture: suitable
western blot: suitable
杂质
HIV I and HIVII, HCV and HBsAg, tested negative
≤0.007% Fatty Acids
溶解性
H2O: soluble 50 mg/mL, clear to slightly hazy
UniProt登记号
储存温度
2-8°C
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
基因信息
human ... ALB(213)
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一般描述
白蛋白是人体中丰度最高的血浆蛋白。分子量为66.5 kDa。
应用
利用人血清白蛋白已用作：
- 作为CPT-11（irinotecan，Campto）和SN-38的载体研究其与人血浆蛋白的结合作用
- 研究水和乙腈（AN）蒸气对人血清白蛋白的吸附作用
- 研究其对伤口愈合过程的效应
生化/生理作用
血清白蛋白主要介导二价阳离子转运、脂肪酸和药物复合物的形成和转运。血清中的白蛋白水平表明晚期肝病中的疾病进展。低身体体重和血清白蛋白减少与结肠直肠癌有关。
血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白，对调节血液的胶体渗透压至关重要。研究还发现白蛋白可结合外源物质，特别是药物（例如布洛芬、华法林），并强烈影响其药代动力学。导致白蛋白氧化还原状态变化的氧化应激对其生理功能具有广泛的影响。
制备说明
由白蛋白（A1653）制备
其他说明
更多信息参见人血清白蛋白。
免责声明
仅供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
法规信息
常规特殊物品
Jasper V Been et al.
Respiratory research, 10, 116-116 (2009-11-26)
Preterm infants are highly susceptible to lung injury. While both chorioamnionitis and antenatal steroids induce lung maturation, chorioamnionitis is also associated with adverse lung development. We investigated the ability of bronchoalveolar lavage fluid (BALF) from ventilated preterm infants to restore
J Barré et al.
Clinical chemistry, 31(1), 60-64 (1985-01-01)
Equilibrium dialysis, ultrafiltration, and ultracentrifugation were compared to determine their reliability and applicability in the study of binding of an anticonvulsant drug, valproic acid, by plasma proteins. We studied drug binding with pooled serum and with solutions of human serum
S Miyata et al.
The Journal of clinical investigation, 89(4), 1102-1112 (1992-04-01)
Pyrraline is one of the major Maillard compounds resulting from the reaction of glucose with amino compounds at slightly acidic pH. For in vivo studies, monoclonal pyrraline antibodies were raised after immunization of Balb/c mice with keyhole limpet hemocyamin-caproyl pyrraline
Ferenc Zsila
The journal of physical chemistry. B, 117(37), 10798-10806 (2013-09-06)
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein. It can be inferred from the spectroscopic
A J Crowle et al.
Infection and immunity, 55(12), 2945-2950 (1987-12-01)
Historically, sunlight has seemed to fortify antituberculosis resistance. Evidence is presented here suggesting a role for vitamin D in this effect. The active metabolite of this photosynthesized vitamin, 1,25-dihydroxy-vitamin D3 (1,25D), promotes maturation and activation of human monocytes and macrophages
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