所有图片(2)
别名:
ATP 二钠 水合物
线性分子式:
C10H14N5O13P3Na2 · xH2O
CAS号:
分子量:
551.14 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51
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生物来源
microbial (Corynebacterium sp.)
质量水平
检测方案
≥99% (HPLC)
形式
powder
包装
vial of 30 mg
溶解性
water: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O
InChI
1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
InChI key
NTBQNWBHIXNPRU-MSQVLRTGSA-L
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一般描述
腺苷5γ-三磷酸(ATP)是体内能量储存和代谢的核心组分。 ATP用于许多细胞过程，呼吸，生物合成反应，移动和细胞分裂。ATP是许多细胞信号激酶和腺苷酸环化酶产生二级信使CAMP的底物。 ATP为驱动代谢泵提供代谢能。
应用
5′-三磷酸腺苷（ATP）二钠盐水合物用于：
- 在大鼠海马切片培养物中模拟突触信号传导
- 从原代猪肺泡巨噬细胞（PAM）中分离质粒
- 用作热反应激酶缓冲液的成分，用于凝胶激酶检测
ATP是许多酶反应中的辅酶。腺苷5′-三磷酸 (ATP) 二钠盐水合物用于组织制备和维护。
生化/生理作用
P2 嘌呤能激动剂；增加 Ca2+-激活的 K+ 通道的活性；ATP-依赖酶系统的底物
WGK
WGK 2
个人防护装备
Eyeshields, Gloves, type N95 (US)
Mark D A van Logtestijn et al.
PloS one, 10(2), e0117292-e0117292 (2015-02-12)
The stratum corneum (SC) provides a permeability barrier that limits the inflow and outflow of water. The permeability barrier is continuously and dynamically formed, maintained, and degraded along the depth, from the bottom to the top, of the SC. Naturally
NS1 protein of 2009 pandemic influenza A virus inhibits porcine NLRP3 inflammasome-mediated interleukin-1 beta production by suppressing ASC ubiquitination
Park HS, et al.
Journal of Virology, JVI-00022 (2018)
Bio-Protocol
Pizzio GA and Rodriguez PL
Testing, 7(5) (2017)
JuanJuan Duan et al.
Cellular signalling, 58, 44-52 (2019-03-12)
Persistent inflammasome activation contributes to chronic, low grade inflammation. However, it is unclear how the inflammasome activation is sustained after initiation. Here we reported that N4-acetylcytidine (N4A), a nucleoside metabolite, activated microglia and sustained NLRP3 inflammasome activation by inducing HMGB1
Behnam Abbasian et al.
mSphere, 4(5) (2019-09-06)
Urgency urinary incontinence (UUI) and overactive bladder (OAB) can both potentially be influenced by commensal and urinary tract infection-associated bacteria. The sensing of bladder filling involves interplay between various components of the nervous system, eventually resulting in contraction of the
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