所有图片(4)
别名:
3′-膦酸腺苷 5′-磷酰硫酸 锂盐, APPS, PAPS, 活性硫酸盐
经验公式（希尔记法）:
C10H15N5O13P2S · xLi+ · yH2O
CAS号:
分子量:
507.26 (free acid basis)
Beilstein:
8181191
UNSPSC代码:
41106305
eCl@ss:
32160414
NACRES:
NA.51
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形式
powder
质量水平
浓度
≥60%
运输
dry ice
储存温度
−70°C
InChI
1S/C10H15N5O13P2S.4Li.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24;;;;;/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24);;;;;1H2/q;4*+1;/p-4/t4-,6-,7-,10-;;;;;/m1...../s1
InChI key
UGODCLHJOJPPHP-AZGWGOJFSA-J
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应用
3′-磷酸腺苷5′-磷硫酸盐(PAPS)用作磺基转移酶的体内磺化通用硫酸盐供体。 PAPS用于聚糖的硫酸化。 PAPS还用于研究它其生物转运体的分布和功能。
腺苷3′-磷酸5′-磷酸锂盐被用来克隆和研究哺乳动物锂敏感二磷酸3′-核酸酶，以及它如何被肌醇1,4-二磷酸抑制。腺苷3′-磷酸5′-磷酸锂盐同样用于评估高尔基居民PAP-特异性3′-磷酸酶偶联磺基转移酶分析。
质量
主要杂质为腺苷 3′,5′-二磷酸盐、硫酸盐以及氨取代产物。
注意
当暴露在室温条件，会发生快速降解：在37℃条件下每天降解高达17%。我们是干冰运输，尽可能减少运输过程中的降解。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Paul A Dawson
Seminars in cell & developmental biology, 22(6), 653-659 (2011-03-23)
Sulfate (SO(4)(2-)) is an important nutrient for human growth and development, and is obtained from the diet and the intra-cellular metabolism of sulfur-containing amino acids, including methionine and cysteine. During pregnancy, fetal tissues have a limited capacity to produce sulfate
J P Horwitz et al.
Biochimica et biophysica acta, 480(2), 376-381 (1977-02-09)
A practical synthesis of 3'-phosphoadenosine 5'-phosphosulfate (IV) in yields of 68-72% from adenosine 2',3'-cyclic phosphate 5'-phosphate (II) is described. Reaction of II with triethylamine-N-sulfonic acid affords adenosine 2',3'-cyclic phosphate 5'-phosphosulfate (III) which, on treatment with ribonuclease-T2, provides IV. Spleen phosphodiesterase
Cooper, B.P. and Baumgarten, F.E.
Zeitschrift fur Naturforschung, 159 (1980)
Emanuel Smeds et al.
Glycobiology, 20(10), 1274-1282 (2010-06-18)
The signaling of various molecules involved in development and regulation of cell growth are regulated by heparan sulfate (HS). Specific binding of HS to ligand proteins depends on the HS sulfation pattern, where the spacing and number of O-sulfate groups
B D Spiegelberg et al.
The Journal of biological chemistry, 274(19), 13619-13628 (1999-05-01)
Discovery of a structurally conserved metal-dependent lithium-inhibited phosphomonoesterase protein family has identified several potential cellular targets of lithium as used to treat manic depression. Here we describe identification of a novel family member using a "computer cloning" strategy. Human and
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