A1349
Monoclonal Anti-β-Amyloid (17-24) antibody produced in mouse
~1 mg/mL, clone 4G8, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
4G8, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 1:100-1:1000, immunoprecipitation (IP): 1:10-1:100, indirect ELISA: 1:103-1:105, western blot: 1:100-1:1000
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... APP(351)
Immunogen
synthetic peptide corresponding to amino acids 17-24 of the human β amyloid peptide with Glu substituted at position 11, conjugated to KLH.
Physical form
Solution in phosphate buffered saline.
存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
法规信息
新产品
此项目有
Stefania Zappettini et al.
Frontiers in pharmacology, 3, 146-146 (2012-08-07)
Using both in vitro (hippocampal synaptosomes in superfusion) and in vivo (microdialysis) approaches we investigated whether and to what extent β amyloid peptide 1-40 (Aβ 1-40) interferes with the cholinergic modulation of the release of glycine (GLY) in the rat
Chunyi Jiang et al.
Analytical and bioanalytical chemistry, 396(5), 1745-1754 (2010-02-06)
Aβ(1-42) is the proteolytic cleavage product of cleavage of the amyloid precursor protein by β- and γ-secretases. The aggregation of Aβ(1-42) plays a causative role in the development of Alzheimer's disease. To lock Aβ(1-42) in a homogenous state, we embedded
Baiyang Sheng et al.
Neuroscience letters, 450(3), 327-331 (2008-12-06)
Amyloid precursor protein (APP) is expressed ubiquitously but its wrong cleavage only occurs in central nervous system. In this research, overexpression of wild type human APP695 was found to stimulate the adhesion and migration of N2a cells. In the cells
Alina Hategan et al.
Nature structural & molecular biology, 24(4), 379-386 (2017-02-22)
Deposition of amyloid-β plaques is increased in the brains of HIV-infected individuals, and the HIV transactivator of transcription (Tat) protein affects amyloidogenesis through several indirect mechanisms. Here, we investigated direct interactions between Tat and amyloid-β peptide. Our in vitro studies
David A Bateman et al.
Biophysical journal, 96(10), 4260-4267 (2009-05-20)
Abeta42 has been found to associate rapidly to neuronal cells and is the primary constituent of senile plaques. In this study we monitored the aggregation of Abeta42 with living PC12 cells. Using photobleaching Förster resonance energy transfer, we observed one
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