跳转至内容
Merck
CN

主要文件

查看所有文档

A1287

5-阿扎胞苷

Hybri-Max™, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

别名:

4-氨基-1-(β-D-呋喃核糖基)-1,3,5-三嗪-2(1H)-酮, 阿扎胞苷

登录 查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:
C8H12N4O5
化学文摘社编号:
320-67-2
分子量:
244.20
MDL number:
MFCD00006539
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24890525
EC Number:
206-280-2
Beilstein/REAXYS Number:
620461
Form:
lyophilized powder
Quality level:
200
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

biological source

synthetic (organic)

Quality Level

200

grade

Hybri-Max™

sterility

γ-irradiated

product line

BioXtra

form

lyophilized powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

mp

226-232 °C (dec.) (lit.)

solubility

acetic acid: water (1:1): 5 mg/mL, clear, colorless

antibiotic activity spectrum

viruses

mode of action

DNA synthesis | interferes

storage temp.

−20°C

SMILES string

NC1=NC(=O)N(C=N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

InChI

1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1

InChI key

NMUSYJAQQFHJEW-KVTDHHQDSA-N

Gene Information

human ... DNMT1(1786), DNMT3A(1788)

正在寻找类似产品? 访问 产品对比指南

相关类别

General description

化学结构：核苷

Application

5-氮杂胞苷可用于诱导成人骨髓间充质干细胞的体外心肌向分化。它也可用于研究5-氮杂胞苷对骨髓来源的免疫调节性抑制细胞（MDSC）和调节性T细胞（Treg）的影响。
用于研究DNA掺入分子对DNA甲基化过程的影响。

Biochem/physiol Actions

5-氮杂胞苷是脱氧胞苷类似物和去甲基化剂。它可作为急性骨髓性白血病的潜在抗肿瘤药。5-氮杂胞苷通过抑制DNA甲基化来激活被抑制的基因。5-氮杂胞苷还通过改变RNA功能和稳定性来影响蛋白质合成。
一种强效生长抑制剂及细胞毒素剂，抑制 DNA 甲基转移酶，一种基因表达、基因激活和沉默的重要调节机制。
强效生长抑制剂及细胞毒素剂，抑制 DNA 甲基转移酶。

Preparation Note

10mL 无菌细胞培养基可复原一小瓶本品。储备液足以制备 500mL 培养基。最终工作浓度：10μM 5-氮杂胞嘧啶核苷。

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 1A - Muta. 2 - Repr. 1B - STOT RE 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCG1692
SLCB8606
SLBR2274V
SLBD5429V
089K8725

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

5-azacytidine treatment reorganizes genomic histone modification patterns
Komashko VM and Farnham PJ
Epigenetics, 5(3), 229-240 (2010)
DNA methyltransferase inhibitors for cancer therapy
Epigenetics, 5(3), 265-290 (2015)
Manuel Luís Orta et al.
Nucleic acids research, 41(11), 5827-5836 (2013-04-24)
5-Aza-2'-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological diseases and works by being incorporated into DNA and trapping DNMT. It is unclear what DNA lesions are caused by 5-azadC and if such are substrates
Bodoor Yaseen et al.
Rheumatology (Oxford, England), 59(9), 2625-2636 (2020-05-05)
Cytokines released by infiltrating T cells may promote mechanisms leading to fibrosis in scleroderma. The aim of this study was to investigate the role of the Th2 cytokine IL-31, and its receptor IL-31RA, in scleroderma skin and lung fibrosis. IL-31
L H van der Helm et al.
Leukemia research, 37(8), 877-882 (2013-05-01)
The efficacy of azacitidine has been demonstrated in acute myeloid leukemia (AML) patients with 20-30% bone marrow (BM) blasts, but limited data is available on patients with ≥30% blasts. We analyzed 55 newly diagnosed AML patients, treated with azacitidine. The
查看所有相关文献

全球贸易项目编号

货号GTIN
A1287-1VL04061833342046

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持