所有图片(1)
About This Item
经验公式（希尔记法）:
C6H12N2O3
CAS号:
分子量:
160.17
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.26
product name
D-丙氨酸-D-丙氨酸,
检测方案
≥99%
质量水平
形式
powder
颜色
white to off-white
储存温度
−20°C
SMILES字符串
C[C@@H](N)C(=O)N[C@H](C)C(O)=O
InChI
1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4-/m1/s1
InChI key
DEFJQIDDEAULHB-QWWZWVQMSA-N
应用
- Binding Mode-Based Physicochemical Screening Method Using d-Ala-d-Ala Silica Gel and Chemical Modification Approach to Facilitate Discovery of New Macrolactams, Banglactams A and B, from Nonomuraea bangladeshensis K18-0086.: Describes a novel screening method employing D-Ala-D-Ala silica gel to discover new macrolactams with potential antibacterial properties. This technique aids in identifying compounds that inhibit bacterial cell wall synthesis (Kimishima et al., 2024).
生化/生理作用
D-Ala-D-Ala 存在于革兰氏阳性细菌细胞壁中发现的肽聚糖侧链五肽的茎末端。D-Ala-D-Ala 茎末端是万古霉素和替考拉宁等糖肽抗生素的相互作用位点。D-丙氨酸-D-丙氨酸是用于研究 UDPMurNAc-三肽 D-丙氨酰-D-丙氨酸添加（连接酶）酶的动力学的底物。
D-Ala-D-Ala（细菌肽聚糖的末端部分）用于替考拉宁、瑞斯托菌素、万古霉素等抗生素的亲和层析和结合机制研究。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Vivek K Mutalik et al.
PLoS biology, 18(10), e3000877-e3000877 (2020-10-14)
Bacteriophages (phages) are critical players in the dynamics and function of microbial communities and drive processes as diverse as global biogeochemical cycles and human health. Phages tend to be predators finely tuned to attack specific hosts, even down to the
Gareth A Prosser et al.
Antimicrobial agents and chemotherapy, 60(10), 6091-6099 (2016-08-03)
The increasing global prevalence of drug resistance among many leading human pathogens necessitates both the development of antibiotics with novel mechanisms of action and a better understanding of the physiological activities of preexisting clinically effective drugs. Inhibition of peptidoglycan (PG)
I Tytgat et al.
Current medicinal chemistry, 16(20), 2566-2580 (2009-07-16)
DD-ligases catalyze the synthesis of the D-Ala-D-Ala and D-Ala-D-Ser dipeptides or the D Ala-D-Lac depsipeptide in an early step of peptidoglycan synthesis. Their function is essential for bacterial growth and specific to bacteria, making them attractive targets for the development
Ivona Pavkova et al.
Frontiers in cellular and infection microbiology, 7, 503-503 (2018-01-13)
The DsbA homolog of
Olatunde P Olademehin et al.
ACS omega, 6(1), 775-785 (2021-01-19)
Vancomycin is a glycopeptide antibiotic produced by Amycolaptopsis orientalis used to treat serious infections by Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. Vancomycin inhibits cell wall biosynthesis by targeting lipid II, which is the membrane-bound peptidoglycan precursor. The heptapeptide aglycon structure
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