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A0911

[Ile⁷]-血管紧张素 III 乙酸盐水合物

Name: [Ile<SUP>7</SUP>]-血管紧张素 III 乙酸盐 水合物
Brand: SIGMA

≥95% (HPLC)

别名:

Arg-Val-Tyr-Ile-His-Pro-Ile

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About This Item

经验公式（希尔记法）:

C₄₃H₆₈N₁₂O₉ · xC₂H₄O₂ · yH₂O

分子量:

897.08 (anhydrous free base basis)

MDL编号:

MFCD11045994

UNSPSC代码:

12352209

PubChem化学物质编号:

329770638

NACRES:

NA.26

价格与库存信息目前不能提供

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催产素

产品名称

[Ile⁷]-血管紧张素 III 乙酸盐水合物, ≥95% (HPLC)

质量水平

200

方案

≥95% (HPLC)

表单

powder

颜色

white

储存温度

−20°C

SMILES字符串

O.CC(O)=O.CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(C)C)[C@@H](C)CC)C(O)=O

InChI

1S/C43H68N12O9.C2H4O2.H2O/c1-7-24(5)34(40(61)51-31(20-27-21-47-22-49-27)41(62)55-18-10-12-32(55)38(59)54-35(42(63)64)25(6)8-2)53-37(58)30(19-26-13-15-28(56)16-14-26)50-39(60)33(23(3)4)52-36(57)29(44)11-9-17-48-43(45)46;1-2(3)4;/h13-16,21-25,29-35,56H,7-12,17-20,44H2,1-6H3,(H,47,49)(H,50,60)(H,51,61)(H,52,57)(H,53,58)(H,54,59)(H,63,64)(H4,45,46,48);1H3,(H,3,4);1H2/t24-,25-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

InChI key

YXASJLHKVNKIRW-ZPJCNHGSSA-N

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此商品	SCP0118	SCP0207	SCP0260
SCP0245 [Tyr⁸]-Substance P	SCP0118 [Tyr⁰]-C-Peptide / Proinsulin (32-63) Tyr⁰	SCP0207 [Nle^8,18,Tyr³⁴]-PTH 1-34 bovine	SCP0260 [Ac-Tyr¹,D-Phe²]-VIP Antagonist-GRF 1-29
form lyophilized	form lyophilized	form lyophilized	form lyophilized
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
storage condition protect from light	storage condition protect from light	storage condition protect from light	storage condition protect from light
composition Peptide Content, ≥70%	composition Peptide Content, ≥85%	composition Peptide Content, ≥72%	composition Peptide Content, ≥75%

生化/生理作用

In [Ile7]-Angiotensin III (Ile7-AIII) the seventh amino acid of angiotensin III (phe) is replaced with isoleucine. [Ile7]-Angiotensin III (Ile7 AIII) is an angiotensin III (A III) receptor antagonist used to selectively block the action of Angiotensin III.

[Ile7]-Angiotensin III is (Ile7-Ang III) used as a peptide angiotensin receptor antagonist often in comparison with other Ang antagonists such as saralasin.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A comparison of the characteristics of angiotensin receptors in the renal and mesenteric vascular beds of the anesthetized cat.

K L Clark et al.

Journal of cardiovascular pharmacology, 19(4), 515-524 (1992-04-01)

Experiments were performed in anesthetized cats to compare the characteristics of angiotensin receptors in the renal and mesenteric vascular beds. Injection of either angiotensin II (Ang II; 0.3-30 ng) or angiotensin III (Ang III; 0.3-30 ng) directly into the superior

Effects of peptidase inhibition on angiotensin receptor agonist and antagonist potency in rabbit isolated thoracic aorta.

M J Robertson et al.

British journal of pharmacology, 106(1), 166-172 (1992-05-01)

1. Experiments were performed with peptidase inhibitors on rabbit aortic strip preparations, to determine whether endogenous peptidase activity can influence the potency estimates for angiotensin receptor agonists and antagonists in this tissue. 2. Angiotensin II (A II) and angiotensin III

Action of (1-des(aspartic acid), 8-isoleucine) angiotensin II upon the pressor and steroidogenic activity of angiotensin II.

E L Bravo et al.

The Journal of clinical endocrinology and metabolism, 40(3), 530-533 (1975-03-01)

The vascular and steroidogenic responses to (1-Sarcosine, 8-Isoleucine)-, and to (1-Des (Aspartic acid), 8-Isoleucine) angiotensin II were compared in bilaterally nephrectomized, ACTH-suppressed dogs receiving constant infusions of angiotensin II. Aldosterone secretion rate was significantly inhibited by pretreatment with 200 ng/Kg/min

Modulation by angiotensin III of nociception-related and arterial pressure-related neuronal responsiveness in the nucleus reticularis gigantocellularis of the rat.

J Y Chan et al.

Regulatory peptides, 50(3), 247-257 (1994-03-17)

We evaluated possible modulation by angiotensin III (AIII) of the interactive effect of noxious stimuli and elevation in systemic arterial pressure on the responsiveness of neurons in the nucleus reticularis gigantocellularis (NRGC) of the medulla oblongata. Combined extracellular single-neuron recording

Angiotensin III modulates noradrenaline uptake and release in the rat hypothalamus.

M L Papouchado et al.

Journal of autonomic pharmacology, 15(1), 1-8 (1995-02-01)

1. Effects of angiotensin III (A III) on 3H-noradrenaline (3H-NA) total, neuronal and non-neuronal uptake, 3H intracellular distribution and release were studied in vitro in the rat hypothalamus. 2. A III (1 microM) decreased total, neuronal and non-neuronal 3H-NA uptake

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[Ile⁷]-血管紧张素 III 乙酸盐水合物