Anti-Bovine IgG (whole molecule)−Alkaline Phosphatase antibody produced in rabbit

Anti-Bovine IgG (whole molecule)-Alkaline Phosphatase antibody produced in rabbit has been used in

• enzyme linked immunosorbent assay (ELISA)
• development of immunosensors
• western blot analysis

Bovine IgGs are glycoprotein antibodies that regulate immune responses in herds. These antibodies inhibit TLR5 activation upon immunization with native H7 flagellin . Bovine IgG levels can be used for the detection of Johne′s disease and milk adulteration .

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Immunoglobulins (Igs) belongs to immunoglobulin super-family (IgSF). Igs in general, consist of two heavy (H) chains and two light (L) chains. The L chain can be either κ or a λ chain. Each chain contains one NH2-terminal “variable" (V) region and one or more COOH-terminal “constant” (C) regions. Each of which consists of two sandwiched β pleated sheets ′pinned′ together by a disulfide bridge. There are five main classes of Igs based on heavy chain C domains, they are, IgM, IgG, IgA, IgD, and IgE isotypes. IgG can be divided into four subclasses, IgG1, IgG2, IgG3, and IgG4. Each subclass possesses distinct biologic properties.

Purified bovine IgG

Solution in 0.05 M Tris, pH 8.0, containing 1% bovine serum albumin, 1 mM MgCl₂, 50% glycerol, and 15 mM sodium azide