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主要文件

A0550

Sigma-Aldrich

丙氨酸-谷氨酰胺

≥98% (HPLC)

别名:

丙氨酰谷氨酰胺, 丙谷二肽

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25 G
CN¥577.98
250 G
CN¥2,076.21
10 KG
CN¥49,223.06

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预计发货时间May 30, 2025详情


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25 G
CN¥577.98
250 G
CN¥2,076.21
10 KG
CN¥49,223.06

About This Item

经验公式(希尔记法):
C8H15N3O4
CAS号:
分子量:
217.22
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26

CN¥577.98


预计发货时间May 30, 2025详情


获取大包装报价

产品名称

丙氨酸-谷氨酰胺, ≥98% (HPLC)

质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to off-white

SMILES字符串

NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

InChI

1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1

InChI key

HJCMDXDYPOUFDY-WHFBIAKZSA-N

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此商品
B4554B9879391334
BES BioPerformance Certified, suitable for cell culture, ≥99.0%

B4554

BES

BES ≥99.0% (titration)

B9879

BES

BES ULTROL® Grade, ≥99% dry basis (titration), zwitterionic N-substituted aminosulfonic acid buffer

391334

BES

Quality Level

100

Quality Level

-

Quality Level

400

Quality Level

100

form

solid

form

crystalline

form

crystalline

form

solid

pKa (20 °C)

7.15

pKa (20 °C)

-

pKa (20 °C)

-

pKa (20 °C)

7.12

storage temp.

2-30°C

storage temp.

room temp

storage temp.

room temp

storage temp.

15-25°C

应用

L-谷氨酰胺是细胞培养的一种必需补充剂。游离氨基酸 L-谷氨酰胺不稳定,通常会降解成焦谷氨酸。丙氨酰-L-谷氨酰胺(Ala-Gln)和 Gylcyl-L-谷氨酰胺(Gly-Gln)用作细胞培养中,作为稳定化 L-谷氨酰胺的替代运输形式。使用 L-丙氨酰谷氨酰胺代替 L-谷氨酰胺的主要优点是它降低了细胞培养过程中产生的氨水平。[1][2]

生化/生理作用

丙氨酰谷氨酰胺是一种在生物制药生产中广泛使用的 L-谷氨酰胺的替代补充剂。丙氨酰谷氨酰胺还可作为抗氧化剂(过氧化物)和抗凋亡(LPS 诱导)因子。Ala-Gln 已被用于研究损伤和败血症,以及研究辐射对体内亮氨酸和蛋白质代谢的影响。[3][4] Ala-Gln 已被用于研究体外多形核白细胞和髓过氧化物酶活性。[5]

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

  • 技术规格说明书

  • 历史批次信息供参考:

    分析证书(COA)

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    M Holecek et al.
    Amino acids, 22(1), 95-108 (2002-05-25)
    The mechanism by which glutamine produces a favorable effect in the treatment of sepsis, injury, burns and abdominal irradiation is not completely understood. The main aim of this study was to evaluate the effect of alanyl-glutamine (AlaGln) administration on the
    John D Biggers et al.
    Reproductive biomedicine online, 9(1), 59-69 (2004-07-20)
    A comparison of the effects of replacing L -glutamine with either glycyl-L-glutamine or alanyl-L-glutamine in a KSOM-type medium on the development of mouse preimplantation embryos in vitro has been made. Alanyl-L-glutamine has no significant effect on the rates of blastocyst
    G Biolo et al.
    Nutrition (Burbank, Los Angeles County, Calif.), 13(9 Suppl), 52S-57S (1997-09-18)
    The metabolic response to trauma and sepsis involves an increased loss of body proteins. Specific sites of changes of protein and amino acid metabolism have been identified. In skeletal muscle, the rate of proteolysis is accelerated greatly. The rate of
    A Christie et al.
    Biotechnology and bioengineering, 64(3), 298-309 (1999-07-09)
    Although glutamine is a major carbon source for mammalian cells in culture, its chemical decomposition or cellular metabolism leads to an undesirable excess of ammonia. This limits the shelf-life of glutamine-supplemented media and may reduce the cell yield under certain
    T Hassell et al.
    Applied biochemistry and biotechnology, 30(1), 29-41 (1991-07-01)
    Eight independent cell lines accumulated ammonia in culture to concentrations between 1.3 and 2.9 mM. The growth inhibition of such concentrations of ammonium chloride when added to culture medium was variable. The cell lines tested could be divided into 3

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