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Merck
CN

P8296

5-磷酰核糖-1-焦磷酸酶 五钠盐

≥75% (HPLC)

别名:

α-D-核糖二磷酸5-磷酸 五钠盐, 5-磷酸-α-D-核糖基二磷酸酯, 5-磷酸核糖基1-焦磷酸酯 五钠盐, P-Rib-PP, PRPP 五钠盐

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关于此项目

经验公式(希尔记法):
C5H8Na5O14P3
化学文摘社编号:
分子量:
499.98
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6043637
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产品名称

5-磷酰核糖-1-焦磷酸酶 五钠盐, ≥75% (HPLC)

InChI

1S/C5H13O14P3.4Na/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13;;;;/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13);;;;/q;4*+1/p-4/t2-,3-,4-,5?;;;;/m1..../s1

SMILES string

[Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@H](O[C@@H]1COP(O)([O-])=O)OP([O-])(=O)OP([O-])([O-])=O

InChI key

QZAPPJHVNYCTAX-CKJQBBATSA-J

assay

≥75% (HPLC)

form

powder

impurities

<18% water (Karl Fischer)

color

white

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow

shipped in

dry ice

storage temp.

−20°C

Quality Level

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Analysis Note

纯度 ≥ 75%,基于使用乳清苷-5′-磷酸焦磷酸化酶和乳清苷-5′-磷酸脱羧酶混合酶的测定系统。

Application

五钠盐已被用于评估豚鼠空肠平滑肌细胞中毒蕈碱受体阳离子电流与内部钙之间的关系。 它也已被用于细菌细胞壁Mur D酶的生物合成抑制剂的研究中。

General description

核苷酸合成中磷酸核糖基转移酶的底物。

Other Notes

为了全面了解我们针对客户研究提供的各种单糖产品,建议您访问我们的碳水化合物分类页面。

pictograms

Health hazard

signalword

Warning

hcodes

pcodes

Hazard Classifications

STOT SE 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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L D Gegnas et al.
Bioorganic & medicinal chemistry letters, 8(13), 1643-1648 (1999-01-05)
A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.
P Pacaud et al.
The Journal of physiology, 441, 477-499 (1991-09-01)
1. The action of carbachol, which activates muscarinic receptors, was studied in single patch-clamped cells where free internal calcium concentration in the cell (Cai2+) was estimated using the emission from the dye Indo-1. Cells were dialysed with potassium-free caesium solution
Nisreen Wahwah et al.
Scientific reports, 10(1), 19907-19907 (2020-11-18)
Cisplatin is a mainstay of cancer chemotherapy. It forms DNA adducts, thereby activating poly(ADP-ribose) polymerases (PARPs) to initiate DNA repair. The PARP substrate NAD+ is synthesized from 5-phosphoribose-1-pyrophosphate (PRPP), and we found that treating cells for 6 h with cisplatin reduced
Matthew Bratkowski et al.
Cell reports, 32(5), 107999-107999 (2020-08-07)
The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 Å) and active SARM1 (6.8 Å) and provide mechanistic insight into the tight regulation
Boyuan Wang et al.
Molecular cell, 80(1), 29-42 (2020-08-29)
(p)ppGpp is a nucleotide messenger universally produced in bacteria following nutrient starvation. In E. coli, ppGpp inhibits purine nucleotide synthesis by targeting several different enzymes, but the physiological significance of their inhibition is unknown. Here, we report the structural basis of

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