所有图片(1)
About This Item
经验公式（希尔记法）:
C9H12N2Na2O12P2 · xH2O
CAS号:
分子量:
448.12 (anhydrous basis)
Beilstein:
8817400
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
生物来源
synthetic
质量水平
检测方案
≥96.0% (HPLC)
形式
powder
杂质
≤15% water
储存温度
−20°C
SMILES字符串
[Na+].[Na+].[H]O[H].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O
InChI
1S/C9H14N2O12P2.2Na.H2O/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t4-,6-,7-,8-;;;/m1.../s1
InChI key
RHBXRWOXLRCWIZ-LLWADOMFSA-L
应用
尿苷5′-二磷酸二钠盐水合物用于：
- 作为通过液相质谱联用(LC/MS)测定小鼠肿瘤间质液间质液中代谢物水平的标准品
- 作为通过液相色谱-高分辨质谱测定法(LC-HRMS)分析核苷酸的UDP标准品
- 体外处理E6.5视网膜外植体，以研究其对小胶质细胞进入和延伸至胚胎鹌鹑视网膜的影响
生化/生理作用
尿苷5′-二磷酸(UDP)是一种由受损细胞生成的内源性信号分子，以吸引巨噬细胞。UDP促进小胶质细胞的趋化作用和化学增活，以应对神经元损伤。UDP可用作P2Y受体的配体。UDP和尿苷5′-三磷酸(UTP)可用于研究核酸(RNA)生物合成和细胞信号转导。UDP是一种核苷酸，通过磷酸化使UTP成为酶的底物，如RNA聚合酶和GTP酶。这些酶应用范围广泛，从RNA的合成到G蛋白偶联受体(GPCR)和诸如通过鸟嘌呤核苷酸交换因子(GEF)的Rho信号传递等细胞信号分子的调节等。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
María Martín-Estebané et al.
PloS one, 12(8), e0182450-e0182450 (2017-08-02)
Microglial cell precursors located in the area of the base of the pecten and the optic nerve head (BP/ONH) start to enter the retina of quail embryos at the 7th day of incubation (E7), subsequently colonizing the entire retina by
Kenneth A Jacobson et al.
Purinergic signalling, 5(1), 75-89 (2008-07-05)
Although elucidation of the medicinal chemistry of agonists and antagonists of the P2Y receptors has lagged behind that of many other members of group A G protein-coupled receptors, detailed qualitative and quantitative structure-activity relationships (SARs) were recently constructed for several
Caroline Liot et al.
PloS one, 6(8), e23676-e23676 (2011-09-03)
Besides regulation of actin cytoskeleton-dependent functions, Rho GTPase pathways are essential to cell cycle progression and cell division. Rho, Rac and Cdc42 regulate G1 to S phase progression and are involved in cytokinesis. RhoA GDP/GTP cycling is required for normal
Feng Ding et al.
Current topics in medicinal chemistry, 11(23), 2879-2887 (2011-08-10)
The Rho family small GTPases of the Ras superfamily play key roles in regulating diverse signaling pathways that control a myriad of fundamental cellular processes such as cytoskeletal dynamics, cell cycle progression, gene expression, cell polarity, migration and cell transformation.
Sara J Wright et al.
Genetics, 189(1), 165-176 (2011-07-14)
Heterotrimeric (αβγ) G proteins are crucial components of eukaryotic signal transduction pathways. G-protein-coupled receptors (GPCRs) act as guanine nucleotide exchange factors (GEFs) for Gα subunits. Recently, facilitated GDP/GTP exchange by non-GPCR GEFs, such as RIC8, has emerged as an important
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门