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Merck
CN

87917

Sigma-Aldrich

四甲基罗丹明乙酯高氯酸盐

suitable for fluorescence, ≥90% (HPCE)

别名:

TMRE, TMRE 高氯酸盐

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About This Item

经验公式(希尔记法):
C26H27ClN2O7
分子量:
514.95
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.32

质量水平

检测方案

≥90% (HPCE)

形式

solid

溶解性

DMSO: soluble
alcohols: soluble

荧光

λex 540 nm; λem 595 nm in DMSO

适用性

suitable for fluorescence

储存温度

2-8°C

SMILES字符串

[O-]Cl(=O)(=O)=O.CCOC(=O)c1ccccc1-c2c3ccc(cc3[o+]c4cc(ccc24)N(C)C)N(C)C

InChI

1S/C26H27N2O3.ClHO4/c1-6-30-26(29)20-10-8-7-9-19(20)25-21-13-11-17(27(2)3)15-23(21)31-24-16-18(28(4)5)12-14-22(24)25;2-1(3,4)5/h7-16H,6H2,1-5H3;(H,2,3,4,5)/q+1;/p-1

InChI key

NBAOBNBFGNQAEJ-UHFFFAOYSA-M

相关类别

一般描述

四甲基罗丹明乙酯高氯酸盐(TMRE),也称为 TMRE 高氯酸盐,是一种潜在的线粒体染料。TMRE 染色过程是可逆的,不影响细胞的增殖和活力。

含有 TMRE 高氯酸盐的分选细胞不会干扰随后的功能测定,因此是功能活跃、无偏细胞群富集的首选。

应用

高氯酸四甲基罗丹明乙酯(TMRE)用于研究高糖诱导线粒体形态和代谢变化的影响。

TMRE 高氯酸盐也用于研究富勒烯 C 60  对白血病细胞的渗透和随后的光诱导细胞毒性作用。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

其他说明

电位敏感探针测定线粒体膜电位变化

象形图

Exclamation mark

警示用语:

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Yun Shan Chen et al.
Cancer management and research, 11, 7353-7367 (2019-09-10)
The role of endothelin receptor type B (EDNRB) isoform 3 involved in Temozolomide (TMZ)-induced melanoma cell death has not yet been elucidated. The subcellular localization of EDNRB isoform 3 was determined by confocal and immunoblotting assays. Silencing EDNRB isoform 3
Natasha S Barteneva et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 62(4), 265-275 (2014-01-08)
High-speed fluorescence-activated cell sorting is relevant for a plethora of applications, such as PCR-based techniques, microarrays, cloning, and propagation of selected cell populations. We suggest a simple cell-sorting technique to eliminate early and late apoptotic and necrotic cells, with good
Kyle Trudeau et al.
Investigative ophthalmology & visual science, 52(12), 8657-8664 (2011-10-08)
Mitochondrial dysfunction is known to play a role in retinal vascular cell loss, a prominent lesion of diabetic retinopathy. High glucose (HG) has been reported to induce mitochondrial fragmentation and dysfunction in retinal endothelial cells, contributing to apoptosis. In this
D Franskevych et al.
Nanoscale research letters, 12(1), 40-40 (2017-01-17)
Fullerene C60 as a representative of carbon nanocompounds is suggested to be promising agent for application in photodynamic therapy due to its unique physicochemical properties. The goal of this study was to estimate the accumulation of fullerene C60 in leukemic
Phong Lu et al.
Molecular pharmaceutics, 16(8), 3386-3398 (2019-06-27)
Clinical trials involving p53 gene therapy for ovarian cancer failed due to the dominant negative inhibition of wild-type p53 and multiple genetic aberrations in ovarian cancer. To overcome this problem, we have designed a more potent chimeric gene fusion, called

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