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![O-[(N-琥珀酰亚胺基)琥珀酰氨基乙基]-O′-甲基聚乙二醇 2′000](/deepweb/assets/sigmaaldrich/product/structures/426/156/518cf3f3-8b50-4c91-8501-929224a040d2/640/518cf3f3-8b50-4c91-8501-929224a040d2.png)
![O-[(N-琥珀酰亚胺基)琥珀酰-氨乙基]-O′-甲基聚乙二醇 average Mn 750](/deepweb/assets/sigmaaldrich/product/structures/244/886/c80fd8d8-9a62-4a97-be17-32d83ffd1dfb/640/c80fd8d8-9a62-4a97-be17-32d83ffd1dfb.png)
质量水平
方案
≥90%
表单
powder
储存温度
−20°C
SMILES字符串
N1(C(=O)CCC1=O)OC(=O)CCC(=O)COCCO
InChI
1S/C11H15NO7/c13-5-6-18-7-8(14)1-4-11(17)19-12-9(15)2-3-10(12)16/h13H,1-7H2
InChI key
OVPTZXRXNNJKSJ-UHFFFAOYSA-N
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应用
- 用于药物位点特异性释放并增强肿瘤积聚的基质金属蛋白酶-2/9敏感性肽偶联聚合物胶束：制备与体外和体内评估。该研究探讨了甲氧基聚乙二醇琥珀酸N-羟基琥珀酰亚胺酯 （MPEG-S-NHS）在对基质金属蛋白酶-2/9敏感的肽偶联聚合物胶束制备中的用途。这些胶束是为位点特异性药物释放和增强肿瘤靶向性而设计，展示出在先进药物递送系统中的应用前景（Zhang X, Wang X, Zhong W, Ren X, Sha X, Fang X, 2016）[链接]。
联系
Shearwater Polymers 的产品
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
H Matsuyama et al.
Biological & pharmaceutical bulletin, 16(2), 107-111 (1993-02-01)
Purified sphingomyelinase of Streptomyces A9107 (NRRL 15100) was modified with ss-PEG, methoxypolyethyleneglycol succinimidyl succinate, without loss of activity toward sphingomyelin in the mixed micelles with detergents such as sodium deoxycholate and Triton X-100 or toward a water-soluble, synthetic substrate, HNP
M A Croyle et al.
Journal of virology, 75(10), 4792-4801 (2001-04-20)
Most of the early gene therapy trials for cystic fibrosis have been with adenovirus vectors. First-generation viruses with E1a and E1b deleted are limited by transient expression of the transgene and substantial inflammatory responses. Gene transfer is also significantly curtailed
Y P Li et al.
Acta pharmacologica Sinica, 22(6), 549-555 (2001-12-19)
To assess the merits of polyethylene glycol-modified recombinant human tumor necrosis factor alpha (PEG-rHuTNF-alpha). The rHuTNF-alpha was modified with N-succinimidyl succinate monomethoxy polyethylene glycol (SS-PEG) of three different molecular weights. The PEG-rHuTNF-alpha was separated into fractions of various molecular weights
Georgi As Georgiev et al.
Colloids and surfaces. B, Biointerfaces, 59(2), 184-193 (2007-06-26)
Foam thin liquid films (TLF) and monolayers at the air-water interface formed by DMPC mixed with DMPE-bonded poly (ethylene glycol)s (DMPE-PEG(550), DMPE-PEG(2000) and DMPE-PEG(5000)) were obtained. The influence of both (i) PEG chain size (evaluated in terms of Mw) and
H Matsuyama et al.
Chemical & pharmaceutical bulletin, 39(3), 743-746 (1991-03-01)
Phospholipase D from Streptomyces sp. AA586, PLDP, was modified with methoxypolyethylene glycol succinimidylsuccinate (ss-PEG), an active derivative of polyethylene glycol. By titration with trinitrobenzene sulfonate (TNBS), approximately 70% of the free amino groups in the enzyme protein were shown to
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