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质量水平
形式
powder
投料比
Glu:Tyr (4:1)
分子量
20,000-50,000
技术
ligand binding assay: suitable
颜色
white to off-white
储存温度
−20°C
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生化/生理作用
Poly(Glu,Tyr) (poly(Glu,Tyr) 4:1 random copolymer) is used as a substrate for the evaluation of protein tyrosine kinase(s).
Poly(Glu,Tyr) 4:1 is a polyamino acid used in the manufacture of electrochemical biosensors for detection of reactions such as Fenton induced tyrosine oxidation.
其他说明
有关聚氨基酸的其他技术信息,请访问 聚氨基酸常见问题解答资源。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Journal of agricultural and food chemistry, 56(18), 8692-8698 (2008-09-02)
Oxidation of 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) by lactoperoxidase was found to be inhibited by tyrosine-containing random amino acid copolymers but not by tyrosine. Both electrostatic effects and polymer size were found to be important by comparison of negatively and positively charged copolymers
Biosensors & bioelectronics, 26(1), 235-240 (2010-07-17)
In this report, we determined protein tyrosine kinase (PTKs) activity in human epidermoid carcinoma cells (A431) by employing a novel electrochemical method using boron-doped diamond (BDD) electrodes that enables the electrochemical oxidation of tyrosine (Tyr), phosphorylated Tyr (Tyr-P) and sulfated
Diabetes, 49(4), 603-610 (2000-06-28)
The cellular mechanisms for the insulin resistance of pregnancy and gestational diabetes mellitus (GDM) are unknown. The membrane protein plasma cell membrane glycoprotein-1 (PC-1) has been identified as an inhibitor of insulin receptor tyrosine kinase (IRTK) activity. We investigated insulin
Biosensors & bioelectronics, 26(5), 2292-2296 (2010-11-03)
A simple and sensitive electrochemical biosensor was used to detect tyrosine oxidation induced by hydroxyl radicals generated by Fenton reaction (Fe(2+)/H(2)O(2)). Poly(glu, tyr) (4:1) peptides were immobilized on indium tin oxide (ITO) electrode surface via layer-by-layer assembly technique, and Os(bpy)(3)(2+)-mediated
The Journal of biological chemistry, 275(49), 38127-38130 (2000-09-28)
Protein-tyrosine kinases contain a catalytic loop Arg residue located either two or four positions downstream of a highly conserved Asp residue. In this study, the role of this Arg (Arg-318) in the protein-tyrosine kinase C-terminal Src kinase (Csk) was investigated.
商品
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