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About This Item
经验公式（希尔记法）:
C17H13ClNO5P
CAS号:
分子量:
377.72
Beilstein:
6664478
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.83
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应用
Naphthol AS-E磷酸盐已被用作cAMP反应元件结合蛋白（CREB）的抑制剂，以溶解于二甲基亚砜（DMSO）中作为研究中的储存溶液，来验证制癌蛋白M（OSM）可能会赋予针对3-硝基丙酸（3-NP）的神经元抗性的假设。
生化/生理作用
Naphthol AS-E磷酸盐/KG501是一种小分子拮抗剂，具有阻止cAMP反应元件结合蛋白（CREB）通路的能力。它还可在体外干扰Myb-KIX的相互作用并阻断Myb在体内的作用。
其他说明
碱性磷酸酶的组织化学底物，KG-501可通过干扰CREB的KID结构域和CBP（CREB结合蛋白）的KIX结构域之间这一经典的激活剂-共激活因子互作结合，来阻断CREB（cAMP反应元件结合蛋白）依赖性靶基因转录（Ki 10 microM）的cAMP-诱导。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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