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Merck
CN

62962

Sigma-Aldrich

L-α-溶血磷脂酰胆碱

egg yolk, ≥99.0% (TLC)

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别名:
3-sn-溶血磷脂酰胆碱, L-α-Lysolecithin
MDL编号:
UNSPSC代码:
51321705
NACRES:
NA.25

生物来源

egg yolk

描述

zwitterionic

检测方案

≥99.0% (TLC)

形式

powder or solid

组成

16:0, ~69% (fatty acid)
18:0, ~27% (fatty acid)
18:1, ~3% (fatty acid)

溶解性

chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow

官能团

phospholipid

脂质类型

phosphoglycerides

运输

wet ice

储存温度

−20°C

应用


  • The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating: L-α-LPC is explored for its unique interaction with ion channels, suggesting its potential as a tool for studying channel mechanics and developing new therapeutic strategies for diseases linked to cellular mechanics (Mukherjee et al., 2014).

  • Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter: The use of L-α-LPC in enhancing the delivery of gene therapy vectors via aerosol demonstrates its utility in improving the efficiency of gene therapies, particularly for respiratory diseases (Koehler et al., 2005).

生化/生理作用

3-sn-溶血磷脂酰胆碱不仅有助于改善膜的正曲率,还能抑制体外以及大鼠神经末梢和外分泌胰腺中SNARE复合物的解体

其他说明

去膜青蛙精子染色质制剂

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Harvey T McMahon et al.
Nature, 438(7068), 590-596 (2005-12-02)
Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization
Beibei Duan et al.
Molecules (Basel, Switzerland), 26(6) (2021-04-04)
Fat globule size and phospholipid (PL) content in human milk (HM) were investigated. HM was classified into three groups depending on fat content (A < B < C). PL content (mg/100 g HM) was significantly higher in the C group
Priscila M Hiraiwa et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 93(7), 727-736 (2018-08-18)
Trypanosomatid parasites are causative agents of neglected human diseases. Their lineage diverged early from the common eukaryotic ancestor, and they evolved singular mechanisms of gene expression that are crucial for their survival. Studies on unusual and essential molecular pathways lead
Nuclear envelope assembly following mitosis.
R Pfaller et al.
Methods in enzymology, 219, 60-72 (1992-01-01)
Alessandro Luciani et al.
Autophagy, 8(11), 1657-1672 (2012-08-10)
Channel activators (potentiators) of cystic fibrosis (CF) transmembrane conductance regulator (CFTR), can be used for the treatment of the small subset of CF patients that carry plasma membrane-resident CFTR mutants. However, approximately 90% of CF patients carry the misfolded ΔF508-CFTR

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