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主要文件

62962

Sigma-Aldrich

L-α-溶血磷脂酰胆碱

egg yolk, ≥99.0% (TLC)

别名:

3-sn-溶血磷脂酰胆碱, L-α-Lysolecithin

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About This Item

MDL编号:
UNSPSC代码:
51321705
NACRES:
NA.25

生物来源

egg yolk

描述

zwitterionic

方案

≥99.0% (TLC)

表单

powder or solid

组成

16:0, ~69% (fatty acid)
18:0, ~27% (fatty acid)
18:1, ~3% (fatty acid)

溶解性

chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow

官能团

phospholipid

脂质类型

phosphoglycerides

运输

wet ice

储存温度

−20°C

应用


  • 溶血磷脂酰胆碱对机械敏感离子通道MscL的激活模式不同于张力诱导门控:L-α-LPC因其与离子通道之间存在独特的相互作用而受到关注,表明它有可能成为研究通道力学和为细胞力学相关疾病开发新治疗策略的工具(Mukherjee et al., 2014)。

  • 使用气管内导管将增强型辅助病毒依赖型腺病毒制剂气溶胶递送到兔肺部:使用L-α-LPC可增强基因治疗载体的气溶胶递送,表明其能有效提高基因治疗效率,特别是对于呼吸系统疾病(Koehler et al., 2005)。

生化/生理作用

3-sn-溶血磷脂酰胆碱不仅有助于改善膜的正曲率,还能抑制体外以及大鼠神经末梢和外分泌胰腺中SNARE复合物的解体

其他说明

去膜青蛙精子染色质制剂

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Harvey T McMahon et al.
Nature, 438(7068), 590-596 (2005-12-02)
Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization
Priscila M Hiraiwa et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 93(7), 727-736 (2018-08-18)
Trypanosomatid parasites are causative agents of neglected human diseases. Their lineage diverged early from the common eukaryotic ancestor, and they evolved singular mechanisms of gene expression that are crucial for their survival. Studies on unusual and essential molecular pathways lead
Fengfeng Lu et al.
Neuroscience bulletin, 35(3), 434-446 (2019-01-27)
The obstacle to successful remyelination in demyelinating diseases, such as multiple sclerosis, mainly lies in the inability of oligodendrocyte precursor cells (OPCs) to differentiate, since OPCs and oligodendrocyte-lineage cells that are unable to fully differentiate are found in the areas
Nuclear envelope assembly following mitosis.
R Pfaller et al.
Methods in enzymology, 219, 60-72 (1992-01-01)
Beibei Duan et al.
Molecules (Basel, Switzerland), 26(6) (2021-04-04)
Fat globule size and phospholipid (PL) content in human milk (HM) were investigated. HM was classified into three groups depending on fat content (A < B < C). PL content (mg/100 g HM) was significantly higher in the C group

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