53340
L-组氨酸 二盐酸盐
≥99.0% (AT)
别名:
L-Histidine hydrochloride (1:2)
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关于此项目
经验公式（希尔记法）:
C6H9N3O2 · 2HCl
化学文摘社编号:
分子量:
228.08
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
227-890-5
MDL number:
Beilstein/REAXYS Number:
6119230
产品名称
L-组氨酸 二盐酸盐, ≥99.0% (AT)
InChI key
XEJCDBUNISUVGZ-XRIGFGBMSA-N
InChI
1S/C6H9N3O2.2ClH/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);2*1H/t5-;;/m0../s1
SMILES string
Cl.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O
assay
≥99.0% (AT)
form
powder or crystals
optical activity
[α]20/D +6.5±1°, c = 8% in H2O
ign. residue
≤0.1% (as SO4)
color
white
mp
240-245 °C (dec.)
solubility
H2O: soluble, saline: soluble
anion traces
sulfate (SO42-): ≤50 mg/kg
cation traces
As: ≤0.1 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, NH4+: ≤500 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg
Quality Level
Biochem/physiol Actions
L-Histidine is a natural proteinogenic α amino acid useful as a cell growth supplement that support protein and peptide biosynthesis. L-Histidine is studied in a wide range of applications that involve imidazole chemistry and biochemisty.
L-Histidine is a positively charged imidazole-side chain containing α amino acid. It is metabolized to histamine and is a precursor of the dipeptide carnosine. As one of the 22 proteinogenic amino acids L-His is incorporated into proteins by translation processes in vitro. L-Histidine is an essential amino acid added to cell culture media.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jorge A Vila et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(14), 5602-5607 (2011-03-23)
A method is proposed to determine the fraction of the tautomeric forms of the imidazole ring of histidine in proteins as a function of pH, provided that the observed and chemical shifts and the protein structure, or the fraction of
Azzurra Stefanucci et al.
International journal of molecular sciences, 12(5), 2853-2890 (2011-06-21)
A successful design of peptidomimetics must come to terms with χ-space control. The incorporation of χ-space constrained amino acids into bioactive peptides renders the χ(1) and χ(2) torsional angles of pharmacophore amino acids critical for activity and selectivity as with
Amir Abbas Farshid et al.
Indian journal of pharmacology, 45(2), 126-129 (2013-05-30)
Cyclophosphamide (CP), a widely used antineoplastic drug causes hemorrhagic cystitis (HC) mainly via induction of oxidative stress. Both vitamin C and histidine have antioxidant properties. The present study aimed to investigate the effects of oral (p.o.) administration of vitamin C
Ana Reis et al.
Analytical and bioanalytical chemistry, 399(8), 2779-2794 (2011-02-01)
The radical oxidation of isomeric peptides containing one reactive amino acid [histidine (H)] and another less reactive amino acid [glycine (G)] in the form of dipeptides (HG and GH) and tripeptides (HGG, GHG, and GGH) was studied by mass spectrometry
K Bjornsdottir-Butler et al.
International journal of food microbiology, 334, 108815-108815 (2020-09-24)
Histamine or scombrotoxin fish poisoning is caused by ingestion of bacterially produced histamine in fish. Histamine-producing bacteria generally contain the histidine decarboxylase gene (hdc). However, some strains of Photobacterium phosphoreum are known to produce significant levels of histamine, although the
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