质量水平
检测方案
≥90% (HPLC)
形式
powder
旋光性
[α]20/D −24±2°, c = 1% in 0.5 M Na2HPO4
杂质
≤3 mol/mol water (NMR)
运输
wet ice
储存温度
−20°C
SMILES字符串
O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
InChI
1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1
InChI key
HPLNHYUZFVUXFJ-ZVQJTLEUSA-L
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一般描述
5′-三磷酸鸟苷(GTP)是一种嘌呤三核苷酸磷酸。GTP是各种G-蛋白偶联受体(GPCR)GTP酶及细胞信号转导和GTP/GDP循环相关鸟嘌呤核苷酸交换因子(GEF)的底物。如需进行RNA聚合酶转录、DNA/RNA生物合成,请访问G3776产品。
应用
鸟苷 5′-三磷酸钠盐水合物已用于:
- 作为星形胶质细胞膜片钳内液的组成部分,监测小鼠杏仁核切片星形胶质细胞的钙活性。
- 利用电压钳技术记录细胞系中通道电流的溶液。
- 制备内部记录注射溶液,用于将基因传递到机械感觉毛细胞。
- 在通过体积排除色谱法(SEC)分析齐聚反应过程中,促进G界面介导的人septin蛋白同源二聚体的形成。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type N95 (US)
Neuron, 94(2), 271-273 (2017-04-21)
Mechanosensation is essential for various physiological processes, and it is mediated by mechanotransduction channels. Recently, we reported that TMEM150C/Tentonin 3 (TTN3) confers mechanically activated currents with slow inactivation kinetics in several cell types, including dorsal root ganglion neurons (Hong et al.
Development (Cambridge, England), 138(10), 2003-2014 (2011-04-15)
Multicellular organisms use programmed cell death to eliminate unwanted or potentially harmful cells. Improper cell corpse removal can lead to autoimmune diseases. The development of interventional therapies that increase engulfment activity could represent an attractive approach to treat such diseases.
The Journal of biological chemistry, 286(27), 24364-24373 (2011-05-19)
The small GTPase Rab5, which cycles between GDP-bound inactive and GTP-bound active forms, plays essential roles in membrane budding and trafficking in the early endocytic pathway. Rab5 is activated by various vacuolar protein sorting 9 (VPS9) domain-containing guanine nucleotide exchange
The Journal of biological chemistry, 280(12), 11513-11519 (2005-01-15)
The mechanism of desensitization of the nitric oxide (NO) receptor (alpha1.beta1 isoform of soluble guanylyl cyclase, sGC) is not known. Models of the structure of alpha1.beta1, based on the x-ray crystal structure of adenylyl cyclase (AC) suggest the existence of
The Biochemical journal, 293 ( Pt 1), 93-100 (1993-07-01)
A glycoprotein fraction was isolated from rat liver membranes by affinity chromatography on immobilized wheat-germ lectin. Incubation of this fraction with MgATP or MgGTP resulted in a sequential phosphorylation and dephosphorylation of a complex of three polypeptides (118, 128 and
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