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Merck
CN

50239

甘氨酸

≥99.0% (NT), suitable for ligand binding assays, BioUltra

别名:

三甘氨酸, 甘氨酰-甘氨酰-甘氨酸

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关于此项目

线性分子式:
NH2CH2CONHCH2CONHCH2COOH
化学文摘社编号:
556-33-2
分子量:
189.17
NACRES:
NA.26
PubChem Substance ID:
57651245
UNSPSC Code:
12352209
EC Number:
209-122-0
MDL number:
MFCD00036223
Beilstein/REAXYS Number:
1711130

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产品名称

甘氨酸, BioUltra, ≥99.0% (NT)

InChI key

XKUKSGPZAADMRA-UHFFFAOYSA-N

InChI

1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13)

SMILES string

NCC(=O)NCC(=O)NCC(O)=O

product line

BioUltra

assay

≥99.0% (NT)

form

powder

technique(s)

ligand binding assay: suitable

impurities

insoluble matter, passes filter test

ign. residue

≤0.1% (as SO4)

loss

≤0.5% loss on drying, 110 °C

color

white

pH

4.5-6.0 (25 °C, 0.5 M in H2O)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤50 mg/kg
Bi: ≤5 mg/kg
Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.5 M in H2O

UV absorption

λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.10

Quality Level

100

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相关类别

Application

<ul>
<li><strong>靶向PEPT1：提高阿霉素在人肝细胞癌治疗中抗肿瘤疗效的新策略：</strong>研究探索将Gly-Gly-Gly肽用作药物递送效率的潜在增强剂，将其定位为癌症靶向治疗用临床诊断肽开发的宝贵工具（Gong et al., 2017）。</li>
<li><strong>氨基酯甲基丝氨酸和Gly-Gly、Gly-Val和Gly-Gly-Gly肽衍生的亚氨基吡啶锰、铼和钼配合物：肽链的自组装：</strong>本研究展示了Gly-Gly-Gly在复杂金属肽框架合成中的应用，可能用于IVD生产中的高纯度肽应用（&Aacute;lvarez et al., 2012）。</li>
</ul>

Biochem/physiol Actions

用于通过缩二脲反应重现血清蛋白测量和测定氨基三肽酶的底物。

General description

甘氨酸-甘氨酸-甘氨酸或三甘氨酸是一种由三个甘氨酸残基组成的柔性多肽接头，由肽键按线性顺序连接而成。甘氨酸接头连接单一蛋白的多个结构域，而不影响每个结构域的功能。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN9748
BCCN2357
BCCM3608
BCCK0756
BCCK9539

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Vishnu Priyanka Reddy Chichili et al.
Protein science : a publication of the Protein Society, 22(2), 153-167 (2012-12-12)
Linkers or spacers are short amino acid sequences created in nature to separate multiple domains in a single protein. Most of them are rigid and function to prohibit unwanted interactions between the discrete domains. However, Gly-rich linkers are flexible, connecting
Chi-Kit Siu et al.
Journal of the American Society for Mass Spectrometry, 20(6), 996-1005 (2009-03-04)
Fragmentations of tautomers of the alpha-centered radical triglycine radical cation, [GGG(*)](+), [GG(*)G](+), and [G(*)GG](+), are charge-driven, giving b-type ions; these are processes that are facilitated by a mobile proton, as in the fragmentation of protonated triglycine (Rodriquez, C. F. et
Liang Ma et al.
Biochemistry, 49(9), 1954-1962 (2010-02-04)
To improve our understanding of the effects of small solutes on protein stability, we conducted atomistic simulations to quantitatively characterize the interactions between two broadly used small solutes, urea and glycine betaine (GB), and a triglycine peptide, which is a
Angelo Bella et al.
Angewandte Chemie (International ed. in English), 51(2), 428-431 (2011-11-25)
Two faces for one matrix: A single bifaceted cyclopeptide block forms highly branched, porous, and intricate fibrillar networks, which span microscopic dimensions and mimic the extracellular matrix to support cell growth and proliferation. The peptide block has two domains connected
Jiyun Shi et al.
Journal of medicinal chemistry, 51(24), 7980-7990 (2008-12-04)
This report describes the synthesis of two new cyclic RGD (Arg-Gly-Asp) dimers, 3 (E[G(3)-c(RGDfK)](2)) and 4 (G(3)-E[G(3)-c(RGDfK)](2)), and their corresponding conjugates 5 (HYNIC-E[G(3)-c(RGDfK)](2): HYNIC = 6-(2-(2-sulfonatobenzaldehyde)hydrazono)nicotinyl) and 6 (HYNIC-G(3)-E[G(3)-c(RGDfK)](2)). Integrin alpha(v)beta(3) binding affinities of 5 and 6 were determined by
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