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50239

Sigma-Aldrich

甘氨酸

≥99.0% (NT), suitable for ligand binding assays, BioUltra

别名:

三甘氨酸, 甘氨酰-甘氨酰-甘氨酸

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About This Item

线性分子式:
NH2CH2CONHCH2CONHCH2COOH
CAS号:
556-33-2
分子量:
189.17
Beilstein:
1711130
EC 号:
209-122-0
MDL编号:
MFCD00036223
UNSPSC代码:
12352209
PubChem化学物质编号:
57651245
NACRES:
NA.26

产品名称

甘氨酸, BioUltra, ≥99.0% (NT)

产品线

BioUltra

质量水平

100

方案

≥99.0% (NT)

表单

powder

技术

ligand binding assay: suitable

杂质

insoluble matter, passes filter test

灼烧残渣

≤0.1% (as SO4)

缺失

≤0.5% loss on drying, 110 °C

颜色

white

pH值（酸碱度）

4.5-6.0 (25 °C, 0.5 M in H2O)

溶解性

H2O: 0.5 M at 20 °C, clear, colorless

痕量阴离子

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

痕量阳离子

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤50 mg/kg
Bi: ≤5 mg/kg
Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.5 M in H2O

紫外吸收

λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.10

SMILES字符串

NCC(=O)NCC(=O)NCC(O)=O

InChI

1S/C6H11N3O4/c7-1-4(10)8-2-5(11)9-3-6(12)13/h1-3,7H2,(H,8,10)(H,9,11)(H,12,13)

InChI key

XKUKSGPZAADMRA-UHFFFAOYSA-N

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相关类别

Amino Acid Sequence

Gly-Gly-Gly

一般描述

甘氨酸-甘氨酸-甘氨酸或三甘氨酸是一种由三个甘氨酸残基组成的柔性多肽接头，由肽键按线性顺序连接而成。甘氨酸接头连接单一蛋白的多个结构域，而不影响每个结构域的功能。

应用

<ul>
<li><strong>靶向PEPT1：提高阿霉素在人肝细胞癌治疗中抗肿瘤疗效的新策略：</strong>研究探索将Gly-Gly-Gly肽用作药物递送效率的潜在增强剂，将其定位为癌症靶向治疗用临床诊断肽开发的宝贵工具（Gong et al., 2017）。</li>
<li><strong>氨基酯甲基丝氨酸和Gly-Gly、Gly-Val和Gly-Gly-Gly肽衍生的亚氨基吡啶锰、铼和钼配合物：肽链的自组装：</strong>本研究展示了Gly-Gly-Gly在复杂金属肽框架合成中的应用，可能用于IVD生产中的高纯度肽应用（&Aacute;lvarez et al., 2012）。</li>
</ul>

生化/生理作用

用于通过缩二脲反应重现血清蛋白测量和测定氨基三肽酶的底物。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM3608
BCCK0756
BCCK9539
BCCH6014
BCCF8876

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Vishnu Priyanka Reddy Chichili et al.
Protein science : a publication of the Protein Society, 22(2), 153-167 (2012-12-12)
Linkers or spacers are short amino acid sequences created in nature to separate multiple domains in a single protein. Most of them are rigid and function to prohibit unwanted interactions between the discrete domains. However, Gly-rich linkers are flexible, connecting
Sudipta Chakraborty et al.
Bioconjugate chemistry, 21(5), 969-978 (2010-04-15)
This report presents the synthesis and evaluation of (111)In(DOTA-6G-RGD(4)) (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid; 6G-RGD(4) = E{G(3)-E[G(3)-c(RGDfK)](2)}(2) and G(3) = Gly-Gly-Gly), (111)In(DOTA-RGD(4)) (RGD(4) = E{E[c(RGDfK)](2)}(2)) and (111)In(DOTA-3G-RGD(2)) (3G-RGD(2) = G(3)-E[G(3)-c(RGDfK)](2)) as new radiotracers for imaging integrin alpha(v)beta(3)-positive tumors. The IC(50) values
Craig P Schwartz et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(32), 14008-14013 (2010-07-28)
Nitrogen K-edge spectra of aqueous triglycine were measured using liquid microjets, and the effects of Hofmeister-active salts on the spectra were observed. Spectra simulated using density functional theory, sampled from room temperature classical molecular dynamics trajectories, capture all major features
Dipositively charged protonated a3 and a2 ions: generation by fragmentation of [La(GGG)(CH3CN)2]3+.
Tujin Shi et al.
Angewandte Chemie (International ed. in English), 47(43), 8288-8291 (2008-09-26)
Avisek Chatterjee et al.
The Journal of chemical physics, 129(10), 105104-105104 (2008-12-03)
X-ray photoelectron spectroscopy (XPS) has been used to investigate the core-level electronic structures of glycine (G) and its peptides, including glycyl-glycine (GG), diglycyl-glycine (GGG), and polyglycine (poly-G), in their powder forms. Increasing the number of G units in the peptides
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