所有图片(1)
About This Item
经验公式（希尔记法）:
C6H13NO3
CAS号:
分子量:
147.17
Beilstein:
4128096
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26
推荐产品
产品名称
(4S)-4-羟基-L-异亮氨酸, from fenugreek seeds, ≥98.0% (TLC)
生物来源
fenugreek seeds
质量水平
方案
≥98.0% (TLC)
表单
powder or flakes
旋光性
[α]/D +32.5±2.0°, c = 1 in H2O
颜色
white to almost white
储存温度
2-8°C
SMILES字符串
C[C@H](O)[C@H](C)[C@H](N)C(O)=O
InChI
1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5-/m0/s1
InChI key
OSCCDBFHNMXNME-YUPRTTJUSA-N
相关类别
生化/生理作用
胡芦巴（Trigonella foenum-graecum）种子中的 4-羟基异亮氨酸（HIL） 是一种潜在的促胰岛素分泌性（抗糖尿病）和抗肥胖氨基酸。HIL 刺激胰腺细胞葡萄糖依赖性胰岛素分泌。HIL 激活胰岛素受体底物相关的磷酸肌醇 3（PI3）激酶活性。HIL 可降低甘油三酯、游离脂肪酸和胆固醇的血浆水平。
（4S）-4-羟基-L-异亮氨酸（HIL）是一种非蛋白源 α由细菌异亮氨酸双加氧酶（s）活性产生的氨基酸。为了解其促胰岛素的（抗糖尿病）和抗肥胖作用，目前（2S，3R，4S）-HIL 正在研究中。
包装
无底玻璃瓶。内含物装在插入式熔锥内。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
296.6 °F
闪点(°C)
147 °C
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Makoto Hibi et al.
Applied and environmental microbiology, 77(19), 6926-6930 (2011-08-09)
We determined the enzymatic characteristics of an industrially important biocatalyst, α-ketoglutarate-dependent l-isoleucine dioxygenase (IDO), which was found to be the enzyme responsible for the generation of (2S,3R,4S)-4-hydroxyisoleucine in Bacillus thuringiensis 2e2. Depending on the amino acid used as the substrate
Mohammad Reza Haeri et al.
Phytotherapy research : PTR, 23(1), 61-64 (2008-08-06)
Fenugreek (Trigonella foenum graecum L) is a plant traditionally used for the treatment of diabetes. It contains an unusual amino acid, 4-hydroxyisoleucine, demonstrated to have insulinotropic and antidiabetic properties in animal models. Here we examine the effect of 4-hydroxyisoleucine on
Y Sauvaire et al.
Diabetes, 47(2), 206-210 (1998-03-31)
We report the characterization of a new insulinotropic compound, 4-hydroxyisoleucine. This amino acid has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties. 4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range
Tadigoppula Narender et al.
Bioorganic & medicinal chemistry letters, 16(2), 293-296 (2005-10-26)
Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant. From the seeds of T. foenum-graecum an unusual amino acid, 4-hydroxyisoleucine 5, has been isolated, which significantly decreased the plasma triglyceride levels by 33% (P<0.002), total cholesterol (TC) by
Jun Ogawa et al.
Applied microbiology and biotechnology, 89(6), 1929-1938 (2010-11-12)
4-Hydroxyisoleucine (HIL) found in fenugreek seeds has insulinotropic and anti-obesity effects and is expected to be a novel orally active drug for insulin-independent diabetes. Here, we show that the newly isolated strain Bacillus thuringiensis 2e2 and the closely related strain
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