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安全信息

426R-1

Sigma-Aldrich

STAT6 (EP325) Rabbit Monoclonal Primary Antibody

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别名:
Signal Transducer and Activator of Transcription
UNSPSC代码:
12352203

生物来源

rabbit

质量水平

100
500

偶联物

unconjugated

抗体形式

culture supernatant

抗体产品类型

primary antibodies

克隆

EP325, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形式

buffered aqueous solution

种属反应性

human

包装

vial of 0.1 mL concentrate (426R-14)
vial of 0.1 mL concentrate Research Use Only (426R-14-RUO)
vial of 0.5 mL concentrate (426R-15)
vial of 1.0 mL concentrate (426R-16)
vial of 1.0 mL concentrate Research Use Only (426R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (426R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (426R-17)
vial of 7.0 mL pre-dilute ready-to-use (426R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (426R-18-RUO)

制造商/商品名称

Cell Marque™

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同位素/亚型

IgG

控制

solitary fibrous tumor

运输

wet ice

储存温度

2-8°C

可视化

nuclear

基因信息

human ... STAT6(6778)

相关类别

一般描述

STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors. Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm. STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays. NAB2-STAT6 fusion transcriptions have been reported in the majority of solitary fibrous tumors but not in meningiomas, hemangioblastomas, schwannomas, and hemangiomas. This makes STAT6 a useful marker in distinguishing solitary fibrous tumors from other morphologically similar tumors.

质量


IVD
IVD
IVD
RUO

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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Note: This IFU may not apply to your specific product lot.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Alison L Cheah et al.
Pathology, 46(5), 389-395 (2014-07-01)
Recurrent NAB2-STAT6 gene fusions have recently been identified in solitary fibrous tumour by next generation sequencing. Our aim was to examine the sensitivity and specificity of STAT6 immunohistochemistry for solitary fibrous tumour versus other morphologically similar soft tissue tumours. STAT6
Christian Koelsche et al.
Histopathology, 65(5), 613-622 (2014-04-08)
Nuclear relocation of STAT6 has been shown in tumours with NAB2-STAT6 fusion, and has been proposed as an ancillary marker for the diagnosis of solitary fibrous tumours (SFTs). The aim of this study was to verify the utility of STAT6
Leonille Schweizer et al.
Acta neuropathologica, 125(5), 651-658 (2013-04-12)
Non-central nervous system hemangiopericytoma (HPC) and solitary fibrous tumor (SFT) are considered by pathologists as two variants of a single tumor entity now subsumed under the entity SFT. Recent detection of frequent NAB2-STAT6 fusions in both, HPC and SFT, provided

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