生物来源
ox bile
质量水平
描述
anionic
检测方案
≥99.0% (T)
形式
powder
旋光性
[α]20/D +54±1°, c = 1% in ethanol
分子量
392.57 g/mol
杂质
≤1% cholic acid (TLC)
mp
170-175 °C
171-174 °C (lit.)
官能团
carboxylic acid
SMILES字符串
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
InChI
1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1
InChI key
KXGVEGMKQFWNSR-LLQZFEROSA-N
基因信息
human ... ATIC(471)
正在寻找类似产品? 访问 产品对比指南
一般描述
脱氧胆酸是一种两亲分子，是胆汁酸的重要组成部分。它包括3α和12α位取代的羟基和支链末端的羧基。这些组成成分可对分子的亲水性产生影响并且疏水环戊烯并菲形成其中心。
应用
使用脱氧胆酸用作：
- 体外测定中的菌丝抑制化合物，以研究胃肠道中白色念珠菌的菌丝形态发生
- 一种用于估计细胞团块中毒素浓度的内部标准品
- 采用超高效液相色谱三重四极杆质谱联用技术定量在接受治疗的小鼠各种样品中定量测定BA的胆汁酸(BA)颗粒
生化/生理作用
脱氧胆酸的两亲性特性可显著有助于溶解、乳化和吸收体内的脂肪、维生素和胆固醇等。肠内脱氧胆酸含量高可通过诱导氧化应激和DNA损伤导致结肠直肠癌。它是一种致癌和促肿瘤因子。
其他说明
用于β-肾上腺素能受体的增溶
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Preparation and characterizations of a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid conjugates and self-aggregates
Wang F, et al.
Carbohydrate Polymers, 84, 1192-1200 (2011)
E Nedivi et al.
The Journal of biological chemistry, 259(9), 5803-5808 (1984-05-10)
Agonist, but not antagonist, protects the beta-adrenergic receptor from inactivation during solubilization in deoxycholate. Protection is apparently due to locking of the agonist in the receptor, a high affinity interaction induced or stabilized by this detergent. The guanyl nucleotide-binding protein
Jeffery L Smith et al.
Hepatology (Baltimore, Md.), 39(6), 1673-1682 (2004-06-09)
Focal biliary cirrhosis causes significant morbidity and mortality in cystic fibrosis (CF). Although the mechanisms of pathogenesis remain unclear, bile acids have been proposed as potential mediators of liver injury. This study examined bile acid composition in CF and assessed
J Stadler et al.
Cancer letters, 38(3), 315-320 (1988-01-01)
Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous
Thierry Claudel et al.
Arteriosclerosis, thrombosis, and vascular biology, 25(10), 2020-2030 (2005-07-23)
Bile acids are the end products of cholesterol metabolism. They are synthesized in the liver and secreted via bile into the intestine, where they aid in the absorption of fat-soluble vitamins and dietary fat. Subsequently, bile acids return to the
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门