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Merck
CN

17928

Sigma-Aldrich

O-Methyl-O′-succinylpolyethylene glycol 2′000

别名:

Polyethylene glycol, O-(Succinyl)-O′-methylpolyethylene glycol 2′000, Polyethylene glycol 2′000 monomethyl ether succinate

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About This Item

线性分子式:
CH3O(CH2CH2O)nCOCH2CH2COOH
CAS号:
MDL编号:
UNSPSC代码:
51171641
NACRES:
NA.26

表单

powder

质量水平

分子量

Mr ~2100

mp

50-53 °C

Ω端

carboxylic acid

α端

methoxy

储存温度

−20°C

应用

Polyethylene glycol 2000 is used in the construction of biomaterials such as biopolymers, micelles and nanostructures.

生化/生理作用

O-Methyl-O′-succinylpolyethylene glycol 2′000 is a modified monomethoxypolyethylene glycol (mPEG) wherein the hydroxyl groups are succinylated by succinic anhydride. This succinylated mPEG can then be used to synthesize tolerogenic mPEG conjugates of peptides. Tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

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Hattori Y, Nagaoka Y, Kubo M, et al.
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Peptide/protein-polymer conjugates: synthetic strategies and design concepts.
Gauthier MA, Klok HA.
Chemical Communications (Cambridge, England), 21, 2591-2611 (2008)
Sabrina Hoffmann et al.
Immunology letters, 136(1), 13-20 (2010-11-30)
T-cell recognition of peptide-MHC complexes on APCs requires cell-cell interactions. The molecular events leading to T-cell activation have been extensively investigated, but the underlying physical binding forces between T-cells and APCs are largely unknown. We used single cell force spectroscopy
M Z Atassi et al.
Journal of protein chemistry, 10(6), 623-627 (1991-12-01)
Recent studies from this laboratory showed that tolerogenic peptide conjugates are very effective reagents for obtaining epitope-specific immunosuppression of antibody responses to immunopathogenic sites on multideterminant complex protein antigens. This paper describes the procedure for synthesis of well-defined conjugates of

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