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Merck
CN

16758

Sigma-Aldrich

泊洛沙姆407

purified, non-ionic

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别名:
聚(乙二醇)- 嵌段 - 聚(丙二醇)- 嵌段 - 聚(乙二醇)
CAS号:
MDL编号:
UNSPSC代码:
12352104
NACRES:
NA.25

质量水平

形式

powder

质量

purified

杂质

≤1.0% water

pH值(酸碱度)

5.0-7.5

溶解性

soluble, clear, colorless

痕量阳离子

Al: ≤5 mg/kg
As: ≤0.05 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤50 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤1000 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

紫外吸收

λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2

适用性

no residue for filter test

储存温度

2-8°C

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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一般描述

泊洛沙姆407是一种水溶性非离子表面活性剂,具有低毒性和良好的增溶能力。这种三嵌段共聚物由疏水的聚氧丙烯(POP)残基和两侧亲水的聚氧乙烯(POE)单元组成。

应用

泊洛沙姆407已被用于:
  • 作为脂蛋白脂肪酶活性的抑制剂,以评估小鼠肝脏极低密度脂蛋白 (VLDL)-甘油三酯(TG)的分泌
  • 用于小鼠VLDL分泌测定
  • 溶解在磷酸盐缓冲盐水(PBS)中,通过腹膜内注射进小鼠以产生肝甘油三酯

生化/生理作用

泊洛沙姆407 (P407)在特定的聚合物浓度和温度以上表现出可逆的胶凝特性。泊洛沙姆407-基无菌注射制剂是药物传递的优秀候选物。P407热敏水凝胶广泛用作粘膜药物传递系统,因为它们不会刺激粘膜。P407被美国食品和药物管理局(FDA)称为“非活性成分”,适用于多种药物产品,如口服溶液、悬浮液和吸入制剂。

相关产品

产品编号
说明
价格

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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